郑州地区汉族糖尿病合并冠心病患者脂蛋白脂酶多态性

目的探讨脂蛋白脂酶(LPL)在2型糖尿病和糖尿病合并冠心病发病中的作用机制。方法测定糖尿病和糖尿病合并冠心病患者外周血白细胞LPL内含子6的PvuⅡ和内含子8的HindⅢ多态性，以及血清中甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-c)等的水平。结果糖尿病及糖尿病合并冠心病患者外周血LPL基因PvuⅡ和HindⅢ的等位基因P、H频率与对照组相比较无显著性差异。糖尿病和糖尿病合并冠心病患者LPL基因PvuⅡ多态性中的P ／P 基因型患者的TG、TC和LDL-c水平高于非P ／P 患者和对照组，HDL—c水平低于非P ／P 患者和对照组。结论LPL基因PvuⅡ突变位点与糖尿病合并冠心病患者体内脂质代谢紊乱有关，可通过了解LPL基因多态性以了解糖尿病和糖尿病合并冠心病脂质代谢紊乱的状况。

Polymorphism of Lipoprotein Lipase in Han patients with diabetic coronary heart disease in Zhengzhou

Objective To investigate the effect of Lipoprotein lipase(LPL) in the development of diabetic coronary heart disease(CHD).Methods Polymorphism in intron 6 Pvu II and intron 8 Hind III of LPL gene,serum levels of triglyceride (TG),total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-c) were determined in healthy subjects,patients with diabetes and patients with diabetic CHD.Results The frequencies of P+ and H+,the ratios of genotype in LPL gene showed no difference among all the three groups.There were much higher in TG,TC and LDL-c in genotype P+/P+patients with diabetes or diabetic CHD than non-P+/P+ and healthy subjects,and HDL-c were significantly lower in P+/P+ patiens.Conclusion the mutation of Pvu II in LPL gene may play a role in hyperlipaemia in diabetes or diabetic CAD,so we hope it will be helpful to express the condition of hyperlipaemia in diabetes.