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| 樟子松针叶中二萜类成分研究 | |
| 引用本文： | 张蓉,段宏泉,姚智,潘勤,张富赓.樟子松针叶中二萜类成分研究[J].中国中药杂志,2006,31(23):1956-1959. |
| 作者姓名： | 张蓉 段宏泉 姚智 潘勤 张富赓 |
| 作者单位： | 1. 天津医科大学,药学院,天津,300070 2. 天津医科大学,基础医学院,天津,300070 3. 天津中新药业集团股份有限公司,研究开发中心,天津,300457 |
| 摘 要： | 目的：研究樟子松针叶中的化学成分。方法：以硅胶柱色谱、制备高效液相色谱纯化,得到单体化合物,根据各种有机波谱鉴定结构。结果：分离鉴定了6个化合物,分别为松叶酸(pinifolic acid,1),15-oxo-8(17)-labden-18-oic acid(2),15-acetoxy-labd-8(17)-en-18-oic acid(3),去氢松香酸(dehydroabietic acid,4),7α-羟基去氢松香酸(7α-hydroxydehydroabietic acid,5),7β-羟基去氢松香酸(7β-hydroxydehydroabietic acid,6)。结论：化合物3～6均为首次从该植物中分离鉴定,化合物3为新天然产物。细胞毒实验显示化合物2,4～6对Hela和A549细胞具有一定的细胞毒作用。 |
| 关 键 词： | 樟子松 针叶 二萜类 抗癌活性 |
| 文章编号： | 1001-5302（2006）23-1956-04 |
| 收稿时间： | 2005-09-10 |
| 修稿时间： | 2005-09-10 |
Studies on diterpenes in needles of Pinus sylvestris |
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| ZHANG Rong ;DUAN Hong-quan ;YAO Zhi ;PAN Qin ;ZHANG Fu-geng.Studies on diterpenes in needles of Pinus sylvestris[J].China Journal of Chinese Materia Medica,2006,31(23):1956-1959. | |
| Authors: | ZHANG Rong ;DUAN Hong-quan ;YAO Zhi ;PAN Qin ;ZHANG Fu-geng |
| Institution: | 1. The School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; 2. College of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; 3. Research and Development Center of Zhongxin Pharmaceuticals Group Co. Ltd. , Tianjin 300457, China |
| Abstract: | OBJECTIVE: To research the constituents in needles of Pinus sylvestris. METHOD: Repeated column chromatography and preparation HPLC are used for compound isolation, and their structures were elucidated on the basis of spectral data analysis. RESULT: Six compounds, pinifolic acid (1), 15-oxo-8 (17) -labden-18-oic acid (2) , 15-acetoxy-labd-8 ( 17)-en-18-oic acid (3), dehydroabietic acid (4), 7alpha-hydroxydehydroabietic acid (5), 7beta-hydroxydehydroabietic acid (6) were isolated from the needles of P. sylvestris. CONCLUSION: Compound 3-6 were isolated from the needles of P. sylvestris for the first time, and compound 3 is a new natural product. The petroleum ether and EtOAc extracts showed significant cytotoxic effects to Hela and A549. Compounds 2, 4-6 revealed a positive distinction compared to the control group. |
| Keywords: | Pinus sylvestris needles diterpenes anti-tumor activity |
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