益肾降浊汤对脑缺血再灌注大鼠海马组织超微结构的影响

目的：观察益肾降浊汤对大鼠脑缺血再灌后海马组织超微结构的影响。方法：对大鼠进行双侧颈总动脉缺血再灌注，于术后第1、7、15d取海马电镜制样、观察。结果：模型大鼠术后1d神经细胞内线粒体肿胀、嵴断裂，空泡样变；7d神经元变性、核碎裂强皱缩；15d有胶质细胞增生。治疗组脑组织的损伤性变化明显轻于模型组。结论：益肾降浊汤可明显减轻脑缺血再灌注后的神经元损伤，对神经元有保护作用。

Effect of YishenJiangzhuo decoction on the ultrastructure of hippocampal by cerebral ischemia reperfusion in rats

Objective: To observe the effect of YishenJiangzhuo decoction on the ultrastructure of hippocampal by cerebral ischemia reperfusion in rats. Methods: Cerebral ischemia reperfusion was performed by means of occluding common carotid artery of rat. The hippocampal was extracted to be made specimen for observing by electron microscope on 1 th ?7 th and 15 th day postoperation. Results: It was found mistochondrial swelling, crest breaking and vacuolar degeneration in the nerve cell of model rat on the day, and found neuron degeneration, karyorrhexis or karyopyknosis on 7 th day. Gliocyte hyperplasia could be found on 15 th day. The damage change of hippocampal of the treated group was patently lighter than that of the model group. Conclusion: YishenJiangzhuo decoction could significantly reduce the neuron damage induced by cerebral ischemia reperfusion, and had the important effect on protecting the neurons.