| 肿瘤坏死因子的抗病毒作用研究 |
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| 引用本文： | 贾凤兰 肖雷. 肿瘤坏死因子的抗病毒作用研究[J]. 解放军医学杂志, 1990, 15(5): 328-331 |
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| 作者姓名： | 贾凤兰 肖雷 |
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| 作者单位： | 北京军区总医院肝病研究所(贾凤兰，贾克明)，中国医学科学院肿瘤研究所(肖雷)，中国医学科学院肿瘤研究所(吴旻) |
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| 摘 要： |
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| 关 键 词： | 肿瘤坏死因子 抗病毒作用 |
STUDIES ON ANTIVIRAL EFFECT OF TUMOR NECROSIS FACTOR(TNF) |
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| Jia Fenglan,Jia Kerning. STUDIES ON ANTIVIRAL EFFECT OF TUMOR NECROSIS FACTOR(TNF)[J]. Medical Journal of Chinese People's Liberation Army, 1990, 15(5): 328-331 |
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| Authors: | Jia Fenglan Jia Kerning |
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| Affiliation: | Jia Fenglan,Jia Kerning.Institute of Hepatology,General Hospital 01 Beijing Com-mand,PLA.Xiao Lei,Wu Min.National Laboratory of Molecular Oncology,Cancer Institute.Chinese Academy of Medical Sciences,Beijing. |
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| Abstract: | This paper reports the anti-influenza virus (A3/Ya Feng 87-2 strain,H3N2,HA:1280.EID50:10-8 and anti-vesicular stomatitis virus (VSV,TCID50:10-7) activity of TNF.Influenza virus produces cytopathic effects (CPE:++-++++) after being incubated with MDCK cell line for 48 h.TNF has not only suppressed the development of cytopathic effects,but the percentage of viable cells is increased in a dose-dependent manner in cells treated with different doses of TNF.TNF also shows anti-VSV effect on wish cells.We have observed that TNF inhibits VSV mediated cytopathic effect in three different experimental times (add TNF 2h before virus infection,add TNF at the same time with virus,add TNF 2h after virus infection). |
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| Keywords: | Tumor necrosis factor (TNF) Influenza virus Vesicular stomatitis virus (VSV) Antiviral effect of TNF |
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