| 日本大耳兔胆管电灼损伤致瘢痕狭窄模型的建立 |
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| 引用本文： | 纳钊,邹浩,魏东,张小文,沈需,王滔.日本大耳兔胆管电灼损伤致瘢痕狭窄模型的建立[J].昆明医学院学报,2011,32(2):7-10,19. |
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| 作者姓名： | 纳钊 邹浩 魏东 张小文 沈需 王滔 |
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| 作者单位： | 1. 昆明医学院,云南昆明,650031
2. 昆明医学院第二附属医院肝胆外二科,云南昆明,650101 |
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| 基金项目： | 云南省科技厅昆明医学院联合专项基金资助项目 |
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| 摘 要： | 目的建立13本大耳兔胆管电灼损伤致瘢痕狭窄模型，用于胆管瘢痕狭窄防治的研究．方法30只日本大耳兔随机分为对照组n=15）和实验组n=15）分别施行假手术和电灼损伤胆管，术后观察动物的一般情况及生存率，术前及术后30d行肝功能检测，MRI影像学、大体形态学和HE染色光镜下观察胆管狭窄情况．结果与对照组比较，实验组30d后生存率无明显差异，肝功能检测结果有统计学意义（P〈0.05），影像学和大体解剖均发现损伤处形成狭窄，狭窄以上胆管扩张，病理观察证实损伤处有纤维化增生改变．结论日本大耳兔胆管电灼损伤致瘢痕狭窄模型可用于胆管瘢痕狭窄防治的研究．
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| 关 键 词： | 电灼损伤 胆管狭窄 瘢痕 动物模型 |
Establishment of The Model of Bile Duct Strictures by Electrocautery Injury in Japanese Rabbits |
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| NA Zhao,ZOU Hao,WEI Dong,ZHANG Xiao-wen,SHEN Xu,WANG Tao.Establishment of The Model of Bile Duct Strictures by Electrocautery Injury in Japanese Rabbits[J].Journal of Kunming Medical College,2011,32(2):7-10,19. |
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| Authors: | NA Zhao ZOU Hao WEI Dong ZHANG Xiao-wen SHEN Xu WANG Tao |
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| Institution: | NA Zhao1),ZOU Hao2),WEI Dong1),ZHANG Xiao-wen2),SHEN Xu1),WANG Tao1)(1)Kunming Medical University,Kunming Yunnan 650031,2)Dept.of Hepatobiliary Surgery,The 2nd Affiliated Hospital of Kunming Medical university,Kunming Yunnan 650101,China) |
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| Abstract: | Objective To establish a animal model of bile duct strictures by electrocautery injury in Japanese rabbits,for studing the prevention and treatment of bile duct stricture.Methods 30 Japanese rabbits were randomly divided into control group(n=15)and experimental group(n=15),sham operation and electrocautery injury of bile duct were applied respectively.The general condition and survival of animals were observed after operation.The hepatic function of animals were examined before operation and after 30 days.T... |
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| Keywords: | Electrocautery injury Bile duct stricture Scar Animal model |
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