苦参碱和氧化苦参碱对二乙基亚硝胺诱发大鼠肝癌作用的影响

目的　研究苦参碱和氧化苦参碱对二乙基亚硝胺诱发大鼠肝癌作用的影响。方法　采用二乙基亚硝胺法诱发大鼠肝癌 ,观察腹腔注射苦参碱 2 5mg·kg-1和氧化苦参碱10 5mg·kg-130d后 ,大鼠肝表面癌结节数、肝 /体重比和血清中丙氨酸氨基转移酶 (ALT)、γ 谷氨酰转肽酶 (γ GT)、碱性磷酸酶 (ALP)的变化。结果　氧化苦参碱组大鼠肝表面癌结节数、肝 /体重比和血清ALT、γ GT明显低于模型组 (P<0 0 5 ) ;苦参碱组大鼠肝表面癌结节数和血清γ GT明显低于模型组 (P <0 0 5 )。结论　苦参碱和氧化苦参碱 ,尤其是氧化苦参碱 ,不仅能保护肝细胞免受损伤 ,而且能抑制肿瘤细胞增长

Effects of matrine and oxymatrine on rat hepatoma induced by diethylnitrosamine

AIM To study the effects of matrine (MT) and oxymatrime (OMT) on rat hepatoma induced by diethylnitrosamine (DEN). METHODS Hepatoma rats induced by DEN for 90 days , were administered with MT 25 mg·kg -1 or OMT 105 mg·kg -1 for 30 days intraperitioneally.The changes of hepatoma nuts and body weight, liver weight, ratio of liver/body weight were recorded and the alanine aminotransterase (ALT), γ glutamyl transferase (γ GT) and alkaline phosphatase (ALP) in serum and the pathological changes of the livers were observed. RESULTS The hepatoma nuts, ratio of liver/body weight serum ALT andγ GT were lower in OMT group compared with model group, while significant changes of hepatoma nodules and γ GT were found in MT group. CONCLUSION MT and OMT, especially OMT, can protect liver cells from damage and inhibit the proliviration of hepatoma cells.