Cytomegalovirus-associated protracted diarrhoea in an immunocompetent boy |
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Authors: | Shimizu Masaki Ohta Kazuhide Wada Hideo Sumita Ryo Yachie Akihiro Koizumi Shoichi |
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Institution: | Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan. mshimizu@ped.m.kanazawa-u.ac.jp |
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Abstract: | AIM: Cytomegalvirus (CMV) gastroenteritis is rarely described in immunocompetent children. We describe here an immunocompetent 1-year-old boy with CMV-associated protracted diarrhoea and discuss the pathogenesis of CMV infection of the gastrointestinal tract. METHODS: Immunohistochemical study was performed using a gastric and duodenal tissue of this patient. Furthermore, the detection of CMV-DNA in stool and urine samples was performed by polymerase chain reaction method. RESULTS: CMV infection was proven by the detection of CMV-DNA in stool and urine samples and CMV-positive cells in the immunoperoxidase preparation from gastroduodenal biopsy. The biopsy specimens showed severe chronic active gastroduodenitis with numerous CD3+ T cells and CD68+ macrophages. CONCLUSIONS: We speculated from these findings that CMV invasion of the mucosal layer induced an intense immune response characterised by massive infiltration of activated T-cells and macrophages in this patient. Although the pathogenesis of CMV-associated gastroenteritis in immunocompetent hosts remains generally unknown, immune mechanism may play some roles in generating the chronic inflammatory lesions. |
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Keywords: | children cytomegalovirus immunocompetent pathogenesis protracted diarrhoea |
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