前列腺活检对血清T-PSA F-PSA及F/T比值的影响

目的 :研究经直肠前列腺穿刺活检对血清总前列腺特异抗原 (T PSA)、游离前列腺特异抗原 (F PSA)及游离 /总前列腺特异抗原 (F/T)比值的影响。方法 :对 36例前列腺活检示良性病变的患者 ,分别于活检前及活检后 0 .5h、1周、30d检测T PSA、F PSA值 ,并计算F/T比值。结果 :活检前及活检后 0 .5h、1周、30d患者血清T PSA分别为 (11.76± 7.82 ) μg/L、(36 .90± 2 4 .76 ) μg/L、(2 4 .36± 16 .18) μg/L和 (12 .2 1± 6 .4 9) μg/L ;F PSA分别为 (2 .4 1± 0 .96 ) μg/L、(2 5 .14± 12 .5 6 ) μg/L、(4 .0 2± 1.90 ) μg/L和 (2 .6 1± 0 .87) μg/L ;F/T比值分别为 0 .2 1± 0 .0 6、0 .6 8± 0 .18、0 .15± 0 .0 4和 0 .2 2± 0 .0 5。与活检前相比 ,活检后 0 .5h、1周T PSA、F PSA值显著升高 (P <0 .0 1、P <0 .0 5 ) ;F/T比值活检后 0 .5h显著升高 (P <0 .0 1) ,活检后 1周时显著降低 (P <0 .0 5 ) ;活检后 30d时 ,以上指标与活检前相比 ,差异均无统计学意义 (均P >0 .0 5 )。结论 :前列腺穿刺活检 ,会导致血清T PSA、F PSA及F/T比值的显著升高 ,临床上要获得有意义的PSA的指标 ,最好在活检 30d后检测

The effect of transrectal prostatic biopsy on serum total and free prostate specific antigen levels and free-to-total prostate specific antigen ratio

Purpose:To evaluate the effect of transrectal prostatic biopsy on serum total and free prostate specific antigen concentrations, and free-to-total prostate specific antigen ratio.Method:Serum total and free PSA was measured immediately before, and 0.5 hour, 1 week and 30 days after prostatic biopsy in 36 men (pathologically confirmed benign prostate disease). The free-to-total prostate specific antigen ratio was also calculated.Result:T-PSA and F-PSA values were significantly increased 0.5 hour and 1 week after biopsy, and both returned to baseline 30 days after biopsy. The F/T PSA ratio was significantly increased 0.5 hour after biopsy and significantly decreased 1 week after biopsy. Thirty days after biopsy, the median of the F/T PSA ratio was not significantly different from the prebiopsy ratio.Conclusion:Prostatic biopsy causes more dramatic increases in both forms of PSA. Measurement of T-PSA, F-PSA levels and the F/T PSA ratio should not be done within 30 days of prostate biopsy.