THE EFFECTS OF SIMULTANEOUS ATROPINE AND LABETALOL ADMINISTRATION ON CARDIOVASCULAR PARAMETERS DURING ANTICHOLINESTERASE POISONING IN ANAESTHETIZED CAT |
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| Authors: | Zainuddin Merican Zahari Mahmud Paden Morat Syed Zahir Idid Khatiza Bi |
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| Affiliation: | Departments of Pharmacology and Physiology, National University of Malaysia, Jalan Raja Muda, Kuala Lumpur, Malaysia |
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| Abstract: | The effects of atropine administration during anticholinesterase poisoning on heart rate, blood pressure and electrocardiographic changes (ECG) were studied in the cat. Administration of atropine intravenously during anticholinesterase poisoning caused a significant increase in heart rate and blood pressure; ECG changes were also seen. The simultaneous intravenous administration of atropine and labetalol during anticholinesterase poisoning abolished the increase in blood pressure and heart rate; ECG readings remained normal. It is suggested that labetalol may be a useful adjuvant in the treatment of anticholinesterase poisoning especially in patients with compromised heart function. |
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| Keywords: | anticholinesterase poisoning, atropine, blood pressure, electrocardiographic changes, heart rate, labetalol. |
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