Dosage plasmatique des D-dimères sur Integra 800® : comparaison avec le dosage sur Vidas® dans le diagnostic d'exclusion des maladies veineuses thromboemboliques |
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| Institution: | 1. Laboratoire de biochimie, centre hospitalier de Roanne, 28, rue de Charlieu, 42328 Roanne cedex, France;2. Laboratoire d''hématobactériologie, centre hospitalier de Roanne, 28, rue de Charlieu, 42328 Roanne cedex, France;3. Service des urgences, centre hospitalier de Roanne, 28, rue de Charlieu, 42328 Roanne cedex, France;1. Cardiovascular department, Ospedali Riuniti and university of Trieste, Trieste, Italy;2. Department of thoracic and cardiovascular surgery, university hospital Jean-Minjoz, 25000 Besançon, France;3. Department of cardiac and thoracic surgery, university hospital Henri-Mondor, Assistance publique–Hôpitaux de Paris, 94000 Créteil, France;1. Université Paris-Descartes, Sorbonne Paris Cité, France;2. AP–HP, hôpital Cochin, service d’hépatologie, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France;1. Équipe hématologie clinique, département d’hématologie clinique, CHRU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France;2. Équipe hémovigilance et aphérèse thérapeutique, département d’hématologie clinique, CHRU de Montpellier, 34295 Montpellier cedex, France;3. Établissement français du sang Pyrénées-Méditerranée, 34184 Montpellier, France;1. Service de dialyse, clinique Reine-Astrid, rue Devant-les-religieuses, 2, 4960 Malmedy, Belgique;2. Service de chirurgie vasculaire, clinique Reine-Astrid, rue Devant-les-religieuses, 2, 4960 Malmedy, Belgique;3. Service d’imagerie médicale, clinique Reine-Astrid, rue Devant-les-religieuses, 2, 4960 Malmedy, Belgique |
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| Abstract: | The D-dimer quantitative test is an exclusive screening tool used by the emergency departments for the exclusion of Deep Venous Thrombosis diseases (DVT). Its negative predictive value is closed to 100%. We compared the diagnostic performance of the D-dimer assay Tinaquant® performed on an Integra 800® to the reference Elisa D-dimer assay Vidas®, which is routinely used in our laboratory as reference test. Interassay reproducibilility (CV) for Tinaquant® is: 2.34% and 2.05% for levels of 1010 and 4830 ng/ml respectively. We investigated 250 patients with the two tests simultaneously. The correlation obtained through a linear regression (R = 0.86) gives the equation: Y (Integra®) = 1.11 × (Vidas®) – 72. The mean D-dimer Vidas® are: 1337 ± 1700 ng/ml vs. Integra®: 1496 ng/ml ± 2379. Ninety percent of the results are concordant at a cutoff of 500 ng/ml. Among the 25 discordant results, 18 are Vidas®(+)/Tinaquant®(–) showing a better specificity for the Tinaquant® test, which is confirmed by imaging results for DVT diagnosis. Only 7 of the 25 give a better specificity for Vidas®. Tinaquant® D-dimer assay demonstrated interesting performances in this study regarding the practicability and the efficiency of the test. It appears to be suitable for the exclusion of DVT diseases and should be studied throughout a larger number of outpatients. |
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