原发性高血压合并高脂血症患者血浆一氧化氮和内皮素含量的临床意义

目的:探讨血浆一氧化氮(NO)、内皮素(ET)在原发性高血压(EH)合并高脂血症患者中的临床意义。方法:检测48例EH患者外周静脉血中NO和ET含量,其中21例合并高脂血症(A组);27例不伴高脂血症(B组)。以24例健康查体人群作为对照(C组)。结果:A组患者血浆NO含量均较B组及C组升高(P<0.05,P<0.01),A组血浆ET含量也较B组及C组升高(P<0.01)。结论:EH及合并高脂血症患者血浆NO和ET含量升高是高血压及其高脂血症的重要病理生理变化之一,反映了血管内皮细胞的功能紊乱。

Plasma Nitric Oxide and Endothelin levels in Essential Hypertension with Hyperlipoproteinemia and Its Clinical Significance

Objective: To investigate the clinical significance of changes in plasma nitric oxide (NO) and endothelin (ET) levels in essential hypertensin (EH) with hyperlipoproteinemia. Methods : Using blood samples obtained from vein, NO and ET levels were determined in 48 patients with EH(21 cases in EH with hyperlipoproteinemia-A group; 27 cease in EH without hyperlipoproteinemia-B group). 24 healthy subjects served as normal controls (C group). Results : Plasma NO levels in A group Was much higher than B group (P<0.05) and, C group (P<0.01). plasma ET levels in A group was much higher than that in B group (P<0.01), C group (P<0.01). Conclusion : The increase in plasma NO and ET might be a pathophysiological characteristic in EH with/without hyperlipoproteinemia, which would deflect endothelial dysfunction of EH.