微乳法制备奥硝唑纳米粉体

目的：制备奥硝唑纳米粉体，改善奥硝唑溶解性能。方法：将奥硝唑／正戊醇溶液作为极性相加入到0．1mol／L的气溶胶OT／异辛烷溶液中，形成油包水型反相微乳，奥硝唑从正戊醇与气溶胶OT形成的胶束结构中析出，得到其纳米粉体。结果：奥硝唑纳米粉体粒径〈100nm，分布均匀。溶解时间由原来粗粉的12min减少到15s，溶解度增加了65．79％。结论：微乳法制备的奥硝唑纳米粉体能改善药物的溶解性能。

Preparation of nanometer ornidazole powder by microemulsion method

Objective： To prepare nanometer ornidazole powder in order to improve solubility of ornidazole. Methods： The ornidazole which was dissolved in 1-pentanol was added into 0.1 mol/L aerosol OT/iso-oetane solution as the water phase to form a W/O reverse microemulsion. The capability of 1-pentanol to dissolve ornidazole was reduced by the reciprocity of 1-pentanol and aerosol OT, which caused the formation of nanometer ornidazole. Results： SEM showed that the nanoparticle of ornidazole had a size less than 100 nm with a narrow dispersion. The solubility research indicated that the dissolving time was reduced from 12 min to 15 s, while its solubility was increased by 65.79%. Conclusion： The method using mieroemulsion to prepare ornidazole nanoparticle is simple, efficient and can improve the solubility of ornidazole.