中药外贴对强直性脊柱炎患者微炎症状态的影响

目的：研究强直性脊柱炎（AS）患者血清微炎症状态指标水平的变化及中药外贴双侧华佗夹脊穴的干预作用以探讨其作用机制。方法：将128例AS患者随机分为治疗组（66例）和对照组（62例）；对照组给予柳氮磺胺吡啶和双侧华佗夹脊穴激光点灼，治疗组在对照组的基础上加用中药外贴双侧华佗夹脊穴。采用全自动酶联免疫分析仪检测血清TNF—α、IL-6、IL-8的水平，乳胶增强免疫比浊法检测CRP的水平；分析HLA—B27阳性和阴性的AS患者血清微炎症状态水平和中药外贴对其的干预作用。结果：AS患者血液微炎症状态指标CRP、IL-6、IL-8、TNF—α的水平较健康人明显升高（P〈0．05），且HLA—B27阳性患者血液微炎症状态指标水平较HLA—B27阴性显著为高（P〈0．05）；经2个疗程治疗后，两组患者CRP、IL-6、IL-8、TNF-α的水平有明显下降（P〈0．05或P〈0．01），且治疗组较对照组明显（P〈0．05或P〈0．01）。结论：AS患者处于微炎症状态，血液存在高水平的CRP、IL-6、IL-8、TNF-α；HLA—B27阳性患者炎症病理损伤程度要大于HLA—B27阴性患者；中药外贴法能消除AS患者炎性因子IL-6、IL-8、TNF—α的刺激，抑制CRP的释放，从而改善其微炎症状态。

Effects of Herbal Plaster on Micro-inflammatory State in Patients with Ankylosing Spondylitis

Objective:To observe the levels of micro-inflammatory indexes and effects of herbal plaster on micro-inflammatory state in patients with ankylosing spondylitis(AS) to explore its mechanisms.Methods:A total of 128 subjects were randomized into two groups:control group in which 62 cases were administered the Sulfasalazine and laser burning at Huatuo-jiaji acupoints,and treatment group in which 66 cases were treated with herbal plaster at Huatuo-jiaji acupoints besides the treatments in control group. Full-aut...