Wall thickness and constrictive responses of the caudal artery in rats with renovascular hypertension |
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| Authors: | M. A. Vlasova A. S. Borovik E. N. Timin A. L. Chernyaev L. M. Mikhaleva O. S. Tarasova I. M. Rodionov |
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| Affiliation: | (1) Laboratory of Cybernetics, A. V. Vishnevskii Institute of Surgery, Russian Academy of Medical Sciences, USSR;(2) Laboratory of Ecological and Geographical Pathology, Institute of Human Morphology, Russian Academy of Medical Sciences, USSR;(3) Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, USSR |
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| Abstract: | In rats with hypertension modeled by the one kidney-one clamp method, constrictory responses of the isolated caudal artery to norepinephrine differed under various perfusion conditions. Vascular reactions in hypertensive rats were more potent at a constant flow rate, and less potent at a constant pressure compared to those in normotensive rats. Previous experiments demonstrated similar changes in constrictory responses of the caudal artery in spontaneously hypertensive rats. It is assumed that these peculiarities of the vascular reactivity during hypertension are determined by thickening of the smooth muscle layer of the vascular wall. Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 159–162, August, 2000 |
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| Keywords: | renovascular hypertension rats vascular reactivity |
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