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| 中药AY注射液的主要药效学研究 | |
| 引用本文： | 朱玲,冯光,唐琼,范爱兰,熊文碧,冯云.中药AY注射液的主要药效学研究[J].四川生理科学杂志,2001,23(4):173-176. |
| 作者姓名： | 朱玲 冯光 唐琼 范爱兰 熊文碧 冯云 |
| 作者单位： | 1. 四川大学华西校区基础与法医学院药理教研室,成都,610041 2. 兰州市第一人民医院药剂科,730030 3. 四川大学华西校区基础与法医学院感染免疫研究室,成都,610041 |
| 摘 要： | 目的评价中药AY注射液对吗啡依赖性小鼠、大鼠催促戒断的治疗作用.方法用扭体法、热板法致痛考察中药AY注射液镇痛作用,并且以剂量递增方法形成吗啡依赖模型,用纳洛酮催促戒断.结果中药AY注射液无显著镇痛效应,注射液大、中、小剂量(10.8g/kg、5.4g/kg、2.7g/kg)均能减轻小鼠注射纳洛酮后跳跃反应,但只有小剂量组可以减轻小鼠体重下降.结论中药AY注射液能明显抑制大鼠的戒断反应,其中中药AY注射液大、中、小剂量能明显抑制大鼠异常姿势、激惹、咬牙、流泪、腹泻、流涎等症状(评分值P＜0.05～0.001);均能明显抑制大鼠体重下降(P＜0.05～0.01). |
| 关 键 词： | 中药AY注射液 吗啡依赖 催促戒断 镇痛 |
The Major Pharmacodynamical Effect of AY Herb Injection |
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| Zhu Ling,Feng Guang,Yang Yunxia,Tang Qiong,Fan Ailan,Xiong Wenbi,Feng Yun.The Major Pharmacodynamical Effect of AY Herb Injection[J].Sichuan Journal of Physiological Sciences,2001,23(4):173-176. | |
| Authors: | Zhu Ling Feng Guang Yang Yunxia Tang Qiong Fan Ailan Xiong Wenbi Feng Yun |
| Institution: | Zhu Ling,Feng Guang1,Yang Yunxia,Tang Qiong,Fan Ailan,Xiong Wenbi,Feng Yun |
| Abstract: | In this study, the anagesic effect of AY herb injection was found with hot plate method and torsion body method. On this base, the mice and rats Morphine-dependent model were established respectively for the evaluation of the detoxication effect of AY herb injection. Naloxone was given to animals to makre them appear abstinence symptoms. The rresults show that AY herb injection have an obvious inhibiting effect of abnormal posture, irritation, bry-mas lachrymation, diarrhoea, salivation and lose of body weight on rats. |
| Keywords: | AY Herb Injection Morphine-dependent Abstinence Analgesic effect |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |