沙雷菌属医院感染的分布特征及耐药性分析

目的了解沙雷菌属感染的分布及对常用抗菌药物的耐药特点,为临床治疗提供参考.方法对全国医院感染监控网79所医院的医院感染沙雷菌属的来源及细菌耐药性进行统计分析.结果 451株沙雷菌属占所有医院感染病原体的1.35%,其中褪色(黏质)沙雷菌占63.19%、液化沙雷菌占21.51%、深红沙雷菌占4.21%;主要分离部位来自呼吸道占60.75%、血液占12.42%、手术部位占10.42%;对头孢哌酮/舒巴坦、亚胺培南、哌拉西林/他唑巴坦、头孢他啶的耐药率较低,分别为3.45%、7.64%、12.50%、28.68%.结论沙雷菌属是引起医院感染的常见病原体,褪色沙雷菌多于其他沙雷菌;不同感染部位分离的沙雷菌种类有差异;沙雷菌耐药严重;临床应针对不同情况合理选用抗菌药物.

Drug Resistance of Serratia in Hospital Infection: Analysis in National Monitoring Net of Hospital Infection

OBJECTIVE To realize the drug-resisting trait of Serratia against common antibacterials to provide reference for clinical therapy. METHODS Resource and drug resistance of Serratia in hospital infection among 79 hospitals, the members of National Monitoring Net of Hospital Infection were statistically analyzed. RESULTS A total of 451 Serratia strains accounted for 1. 35% of all pathogens in hospital infection, consisted of S. marcescens (63. 19%), S. liquefaciens (21. 51%), and S. rubidaea(4.21%). The main localities from where the Serratia isolated were respiratory tracts (60. 75%), blood (12. 42%) and operation sites (10. 42%). Serratia resisted to many antibacterials with different resistance incidence, antibacterials with lower resistant incidence were sulperazono sulbactew (3. 45%), imipenem(7. 64%), piperacillin/tazobactam (12. 50 %) and ceftazidime (28. 68%). CONCLUSIONS Serratia are a common pathogen inducing the hospital infection, and S. marcescens is more often found than others. The kind of Serratia varied in different localities. The drug resistance of Serratia is serious. Antibacterials should be reasonably applied according to different clinical situation.