重症手足口病患儿检测心肌酶 超敏C反应蛋白及白细胞计数的临床意义

目的：探讨手足口病患儿血清中心肌酶、超敏C反应蛋白（hs-CRP）及全血白细胞（WBC）计数的变化及临床意义。方法选取2012-06～2013-04在该院儿科收治的重症手足口病患儿38例，选取普通手足口病患儿138例，并与30例健康对照组进行以上三个项目的检测比较分析。结果重症手足口病患儿血清天门冬氨酸氨基转移酶（ AST ）活性、肌酸激酶（ CK ）活性、肌酸激酶同工酶（ CK-MB ）活性、乳酸脱氢酶（ LDH）活性、α-羟丁酸脱氢酶（α-HBDH）活性、hs-CRP浓度、WBC计数及中性粒细胞百分比均显著高于健康对照组及普通患儿组（ P＜0.05），普通患儿组CK活性、CK-MB活性、hs-CRP浓度、WBC计数较对照组升高，差异有统计学意义（ P＜0.05）。结论联合检测心肌酶、hs-CRP及WBC计数对临床早期诊断手足口病患儿病情有较高的诊断价值。

Clinical signficance on detection of myocardial enzymes,high sensitivity C-reactive protein and peripheral white blood cells count in children with severe hand-foot-mouth disease

Objective To evaluate the clinical significance on detection of myocardial enzymes ,high sensi-tivity C-reactive protein（hs-CRP）and peripheral white blood cells （WBC） count in children with hand-foot-mouth dis-ease（ HFMD） .Methods Thirty-eight children with severe HFMD who treated in our hospital from June 2012 to A-pril 2013 were selected , and 138 children with mild HFMD were selected randomly , and 30 healthy children were used as control group .Serum myocardial enzymes ,hs-CRP and WBC count were tested and the data were analyzed statistically.Results The levels of serum myocardial enzymes ,hs-CRP and WBC in the severe group were signifi-cantly higher than those in the control group and mild group （ P〈0.05 ） .The levels of serum CK ,CK-MB,hs-CRP and peripheral WBC in the mild group were significantly higher than those in the control group （ P〈0.05 ） .Conclusion The combined detection of myocardial enzymes ,hs-CRP and WBC count could have higher value for early diagnosis and assessment of disease condition in the children with HFMD .