| ~(99m)Tc-DTPA肾动态显像评估早期狼疮性肾炎患者肾小球功能 |
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| 引用本文： | 赵成,华冰珠,刘布骏,孙凌云. ~(99m)Tc-DTPA肾动态显像评估早期狼疮性肾炎患者肾小球功能[J]. 实用临床医药杂志, 2010, 14(1): 29-31,35 |
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| 作者姓名： | 赵成 华冰珠 刘布骏 孙凌云 |
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| 作者单位： | 南京大学医学院附属南京鼓楼医院,风湿免疫科,江苏,南京,210008 |
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| 基金项目： | 江苏省科教兴卫工程项目 |
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| 摘 要： | 目的通过99mTc-DTPA肾动态显像评估早期狼疮性肾炎患者肾小球功能损害情况。方法对55例肌酐正常的狼疮性肾炎患者进行99mTc-DTPA肾动态显像测定GFR,同时行血清肌酐、血尿素氮、血清补体C3、C4、ds-DNA测定和24h尿蛋白定量等常规检查。结果55例患者中,GFR在正常范围的仅有15例,占27.3%;GFR下降患者40例,占72.7%。40例肾小球损害的患者中,23例为轻度肾小球损害,17例为中度肾小球损害。肾小球损害组血清肌酐和尿素氮水平均高于正常组,差异具有统计学意义(P0.05);同时肾小球损害组24 h尿蛋白定量明显高于正常组(P=0.006),补体C3、C4水平低于正常组(P0.05)。患者年龄、血清肌酐和24h尿蛋白定量均与GFR值负相关(P0.01)。结论99mTc-DTPA肾动态显像测定GFR,可判断SLE早期肾小球功能损害,为早期发现、早期治疗LN患者及对其进行随访提供依据。
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| 关 键 词： | 狼疮性肾炎 99mTc-DTPA 肾小球滤过率 |
Assessment of renal function with ~(99m)Tc-DTPA renal dynamic imaging in early lupus nephritis |
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| ZHAO cheng,HUA Bin-zhu,LIU Bu-jun,SUN ling-yun. Assessment of renal function with ~(99m)Tc-DTPA renal dynamic imaging in early lupus nephritis[J]. Journal of Clinical Medicine in Practice, 2010, 14(1): 29-31,35 |
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| Authors: | ZHAO cheng HUA Bin-zhu LIU Bu-jun SUN ling-yun |
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| Affiliation: | ZHAO cheng,HUA Bin-zhu,LIU Bu-jun,SUN ling-yun(Department of Rheumatology Gulou Hospital Affiliated to Medical College of Nanjing University,Jiangsu,Nanjing,210008) |
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| Abstract: | Objective To assess the renal glomerulus function in early lupus nephritis with 99mTc-DTPA renal imaging.Methods 55 lupus nephritis patients with normal serum creatinine(SCr) were studied by 99mTc-DTPA renal dynamic imaging,and glomerular filtration rate(GFR) quantitative analysis was performed.Blood urea nitrogen(BUN),SCr,complement C3,C4,ds-DNA and 24 hours urine protein were also measured.Results Only 15 patients had normal GFR,40 patients had decreased GFR.In the latter,23 patients suffered from mild re... |
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| Keywords: | 99mTc-DTPA |
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