Effects of dietary polyamines at physiologic doses in early-weaned piglets |
| |
Authors: | María Sabater-Molina PhD Elvira Larqu PhD Francisco Torrella PhD Javier Plaza Ma Teresa Lozano PhD Antonio Muoz PhD Salvador Zamora PhD |
| |
Institution: | aDepartment of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain;bDepartment of Microbiology, Faculty of Biology, University of Murcia, Murcia, Spain;cDepartment of Cell Biology, Faculty of Biology, University of Murcia, Murcia, Spain;dDepartment of Animal Production, Veterinary School, University of Murcia, Murcia, Spain |
| |
Abstract: | ObjectivePolyamines are essential for many cell functions, and they form part of the composition of maternal milk; despite this, their addition to infant formulas is currently under evaluation. The aim of the present study was to evaluate the effects of milk formulas designed to resemble sow milk supplemented with polyamines at maternal physiologic milk doses on the gut maturation of early-weaned piglets.MethodsWe fed 30 newborn piglets with maternal milk (n = 10), a control milk formula (n = 10), or a milk formula supplemented with polyamines (5 nmol/mL of spermine and 20 nmol/mL of spermidine, n = 10) for 13 d (day 2 after birth through day 15). Several growth and intestinal development parameters were measured.ResultsThe piglets fed the formula containing polyamine at physiologic doses showed significantly increased crypt depth in the small intestine compared with those fed with the control formula. Villus length was correlated to crypt depth. Although there were no differences in the disaccharidase activities between the animals fed the two formulas, alkaline phosphatase and γ-glutamyl transferase activities tended to be higher in the jejunum of those fed the polyamine-supplemented diet. Dietary polyamines did not significantly modify the gut mucosal concentrations of putrescine, spermine, or spermidine.ConclusionMilk formulas supplemented with polyamines at maternal milk physiologic doses slightly enhanced gut growth and maturation in neonatal piglets. |
| |
Keywords: | Polyamines Human milk Small intestine Gut development Piglets |
本文献已被 ScienceDirect 等数据库收录! |
|