Placental protein and hormone measurements in twin pregnancy |
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| Authors: | J G WESTERGAARD Senior Lecturer B TEISNER Associate Professor J HAU Senior Research Fellow J G GRUDZINSKAS Professor |
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| Institution: | Department of Obstetrics and Gynaecology, Odense University Hospital, London;Institute of Medical Microbiology, London;Biomedical Laboratory, University of Odense, Denmark, London;Joint Academic Units of Obstetrics, Gynaecology and Reproductive Physiology, St Bartholomew's Hospital and The London Hospital Medical Colleges, London |
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| Abstract: | Summary. Maternal serum levels of human placental lactogen (hPL), schwangerschaftsprotein 1 (SP1), pregnancy-associated plasma protein A (PAPP-A), placental protein 5 (PP5) and total oestriol (E3) were measured serially in 35 twin pregnancies during the third trimester. Eighteen pregnancies had major complications including dysmaturity of one or both fetuses in nine, premature labour in six, and placental abruption in three. Serum levels of all five variables were higher than in singletons, this distinction being greatest for hPL and lowest for SP1 and E3. The levels of hPL, PP5 and E3 just before delivery were significantly correlated with the total birthweight, a correlation with placental weight being evident only for hPL and PP5. A significant correlation between the five biochemical variables at 33–34 weeks was only seen between hPL and PAPP-A. Protein and hormone levels in. the abnormal twin pregnancies were not apparently different from those in the normal twin pregnancies. These data suggest that only hPL levels biochemically reflect this extreme of fetal and placental growth, but that neither the levels of hPL nor any of the other biochemical indices examined are altered in abnormalities in twin pregnancy |
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