Diagnostic and prognostic value of red blood cell distribution width in sepsis: A narrative review |
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| Affiliation: | 1. Department of Critical Care Medicine, Hospital Nossa Senhora da Conceição, 596 Francisco Trein Ave, Porto Alegre 91350-200, RS, Brazil;2. Department of Critical Care Medicine, Hospital de Clínicas de Porto Alegre, 2350 Ramiro Barcelos Street, Porto Alegre 90035-903, RS, Brazil;3. Hospital de Clínicas de Porto Alegre, 2350 Ramiro Barcelos Street, Porto Alegre 90035-903, RS, Brazil;4. Department of Internal Medicine, School of Medicine, Universidade Federal do Rio Grande do Sul, 721 Jeronimo de Ornelas Ave, Porto Alegre 90040-341, RS, Brazil;1. Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan, China;2. Department of Cardiology, Chengdu Women''s & Children''s Central Hospital, No. 1617, Section 1, Riyue Ave, Chengdu, Sichuan, China;1. Department of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine, 200065 Shanghai, China;2. Sol Sherry Thrombosis Research Center, Temple University, 19140 Philadelphia, PA, USA |
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| Abstract: | Previous studies showed that red blood cell distribution width (RDW) can be used as a prognostic and diagnostic index in various non-hematological diseases, including severe infections and sepsis. Here, we provide a narrative review to summarize the findings of available studies investigating the relationship between RDW and sepsis. Current evidence suggests that increased RDW on admission, both in adults and neonates, may be associated with unfavorable outcomes on the short- and long-term. In patients with suspected sepsis, RDW has modest value for predicting positive blood culture. Accordingly, its diagnostic value for sepsis seems limited, whilts dynamic changes of RDW are associated with outcome of sepsis. Taken together, these results suggest that RDW could be used as a prognostic index in septic patients. |
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| Keywords: | Diagnosis Prognosis RDW Red blood cell distribution width Review Sepsis |
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