布地奈德、特布他林联合氨溴索雾化吸入治疗婴幼儿喘息性疾病的疗效及预后

目的：探讨布地奈德、特布他林联合氨溴索氧气雾化吸入治疗婴幼儿喘息性疾病的临床症状、体征缓解情况，以指导临床治疗。方法：将60例喘息性疾病患儿按随机数字表法分为治疗组和对照组各30例，两组均予常规治疗，治疗组加用布地奈德、特布他林联合氨溴索氧气驱动雾化吸入治疗。记录治疗组在24h后咳嗽、喘息缓解、喘鸣音减轻或消失时间以及经皮血氧饱和度（TcSO2），并对治疗7d后两组疗效进行比较，且随访6个月，统计喘息复发例数及复发率。结果：治疗24h后治疗组在咳嗽、喘息缓解、喘鸣音减轻或消失时间以及TeSO2〉90％与对照组比较差异有统计学意义。治疗组有效率为96．66％，明显高于对照组的66．67％，两组比较差异有统计学意义（P〈0．01）。治疗7d后两组患儿咳嗽、喘息、喘鸣音、湿哆音消失时间以及TeSO2情况、住院时间等方面均优于对照组（P〈0．05）。6个月内喘息复发率分别为19．2％和26．5％，两组比较差异无统计学意义（P〉0．05）。结论：布地奈德、特布他林联合氨溴索氧气雾化吸入治疗婴幼儿喘息性疾病疗效显著，给药途径安全方便，值得临床推广。

The Effect and Prognosis of Budesonide, Terbutaline and Ambroxol Aerosol Inhalation Treatment in Infants and Young Children with Asthmatic Diseases

Objective： To discuss the effect and prognosis of budesonide, terbutaline and ambroxol aerosol inhalation treatment in infants and young children with asthmatic diseases. Methods： Sixty cases of children with asthmatic diseases were divided into a treatment group and a control group equally by random number table method. The two groups were treated with conventional therapy. The treatment group was treated with budesonide, terbutaline and ambroxol through oxygen-driven atomizing inhalation. The relief or disappearance time of cough, wheezing and TcSO2 in the treatment group after 24 hours＇ treatment were recorded. The treatment effects were compared in the two groups after treatment for seven days. Recurrent cases and the recurrence rate were recorded after follow up for six months. Results： After treatment of 24 hours, the relief or disappearance time of cough, wheezing and TcSO2 〉 90% in the treatment group were different to those in the control group. The effective rate of the treatment group was 96.66%, which was significantly higher than that of the control group （66.67%） （P〈0.01）. After treatment for seven days, the relief or disappearance time of cough,wheezing and TcSO2 in the treatment group were superior to those in the control group （ P〈0.05 ）. Asthmatic recurrence rate of the two groups were 19.2% and 26.5 % after six months, respectively. There were no statistical differences （P〉0.05）. Conclusions： Curative effect of budesonide, terbutaline and ambroxol aerosol inhalation is distinct in the treatment of asthmatic diseases in infants and young children. Drug delivery route is safe and convenient.