茵栀黄口服液治疗早产儿黄疸的多中心对照研究

目的：探讨茵栀黄口服液治疗早产儿黄疸的效果及临床价值。方法：血清总胆红素水平增高达光疗标准且以间接胆红素增高为主的早产儿281例，按胎龄分为〈34W组与≥34W组，组内随机分为实验组（茵栀黄口服液＋常规治疗）和对照组（常规治疗），分别检测并比较各组治疗前、治疗3d及治疗完成后（7d）的血清总胆红素水平、总光疗时间，以及相关并发症和不良反应发生情况。结果：〈34W患儿实验组血清胆红素水平于治疗3d、治疗完成后明显下降，与对照组比较差异有统计学意义（P〈0．05，P〈0．01）；≥34W患儿实验组血清胆红素水平于治疗完成后明显下降，与对照组比较差异有统计学意义（P〈0．05）。〈34W、≥34W实验组患儿总光疗时间均少于对照组，差异有统计学意义（P〈0．05）。治疗期间两组患儿均未发现明显不良反应。结论：茵栀黄口服液能有效降低早产儿的血清总胆红素水平，减少总光疗时间。

Multicenter Study of Yinzhihuang Oral Liquid Therapy on Premutrue Infantile Jaundice

Objective： To study the efficacy and clinical values of Yinzhihuang oral liquid on premature neonatal jaundice. Methods： Tow hundred and eight-one cases of premature neonates who suffered jaundice were divided into two teams by the gestationgal age （GA） of 34 weeks. Team 1 for GA〈 34 weeks, while team 2 for GA≥ 34 weeks. All the premuture neonates in each team were randomly assigned to two groups, the treatment group and the control group. The serum bilirubin levels were elevated before therapy, 3 days later and 7 days later. Also, the complications and side effects were observed. Results： In team 1, after treating 3 days and 7 days, the serum bilirubin level of the treatment group was lower than the control ones. There has remarkable or the very remarkable difference with the control group comparison （P〈0.05 or P〈0.01 ）. While in team 2, the same result came after treating 7 days. The total phototherapy time of the treatment group was less than the control group. There were significally difference between the two groups （ P〈0.05 ）. During the treating period in the two groups, no adverse effect was found. Conclusions： Yinzhihuang oral liquid has significally decreased the serum bilirubin level, reduced the total time of phototherapy in preterm infants.