葡萄糖酸锌辅助治疗小儿轮状病毒肠炎疗效观察

目的：探讨口服葡萄糖酸锌辅助治疗轮状病毒肠炎的临床疗效及安全性。方法：对已经确诊为轮状病毒肠炎的患儿186例，按随机数表法分为治疗组94例和对照组92例，对照组给予常规治疗，治疗组在常规治疗的基础上口服葡萄糖酸锌颗粒，年龄〉16个月20mg／d，年龄〈6个月10mg／d，10～14d为1个疗程。结果：治疗组总有效率92．6％，对照组总有效率为75．0％，两组比较差异有统计学意义（P〈0．01）。治疗组中，在年龄≤1岁的50例患儿与〉1岁的44例患儿总有效率分别为96．0％和88．6％，两组比较差异有统计学意义（P〈0．01）。结论：葡萄糖酸锌辅助治疗小儿轮状病毒肠炎临床疗效确切，尤其在≤1岁患儿疗效更好，无明显不良反应，方法简便，价廉易得，适于推广。

Clinical Observation of Therapeutic Effect of Zinc Gluconate Adjuvant Therapy Rotavirus Enteritis in Children

Objective： To investigate the clinical effect of zinc gluconate for rotavirus enteritis and its significance. Methods： One hundred and eighty-six diarrhea patients diagnosed with rotavirus enteritis were enrolled, who were retrospectively analyzed and were randomly divided into a treatment group （n=94） and a control group （n=92）. The control group was given conventional therapy, while the treatment group was given oral zinc gluconate granules on the basis of conventional therapy. Patients were older than or equal to 6 months of age, 20 mg/d; less than 6 months of age, 10 mg/d. The treatment course was 10 - 14 days. Results： The total efficiency of the treatment group （92.6%） was much higher than that of the control group （75.0%） ; there was a significant difference （X^2 =21.48, P〈0.01 ）. In the treatment group, the total efficiency rates of 50 cases less than or equal to 1 year of age and 44 cases in the age of more than 1 year old were 96.0% and 88.6% , respectively. There was a significant difference between the two groups （P〈0. 01 ）. Conclusions ： Clinical curative effect of zinc gluconate adjuvant therapy pediatric rotavirus enteritis is accurate, especially on the age of less than or equal to 1 year old children. It is safe, convenient, economic, and acceptable in the treatment of infantile rotavirus enteritis, and worthy of application.