Effects of supplemental zinc on melanoma metastasis in mice |
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Authors: | M J Murray K L Erickson G L Fisher |
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Affiliation: | 1. Department of Human Anatomy, School of Medicine, University of California, Davis, CA 95616 U.S.A.;2. Toxicology and Health Sciences Section, Batelle Columbus Laboratories, Columbus, OH 43201 U.S.A. |
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Abstract: | The influence of a single intraperitoneal injection of zinc (0.5, 1.5 and 4.5 mg/kg) on the metastasis and subsequent growth of radiolabelled melanoma cells was examined in mice receiving tumor cells s.c. or i.v. 24 h following zinc treatment. Parenteral zinc resulted in increased tumor cell survival in the liver, spleen and lungs of zinc-treated mice 1 day post-injection, while 21-day cell survival was enhanced in the spleens of s.c. injected, zinc-treated mice. Regardless of zinc exposure, relative numbers of s.c. injected tumor cells decreased with time in the lungs and spleen, while increasing in the liver and kidneys. A single dose of zinc can modify the organ distribution and viability of metastatic tumor cells in mice. |
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Keywords: | To whom all correspondence should be addressed. |
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