韶关地区随机献血人群不规则抗体筛查分析

本研究分析韶关地区不规则抗体的频率与分布特征。对韶关地区15033例随机献血者采用抗体筛选细胞、聚凝胺试验和抗人球蛋白试验等作抗体筛查。结果表明：筛出不规则抗体42例,占0.28%,女性不规则抗体者多于男性（P〈0.001）,多为Rh抗体（抗-D;抗-E和抗-C占47.6%）;聚凝胺法漏检2例Le抗体,10个样本混合筛选漏检2例,效价为2的不规则抗体。结论：由于不规则抗体可以导致溶血性输血反应和新生儿溶血病,因此调查本地区不规则抗体对安全输血十分重要。对女性献血者或给重危病人、小儿大量输注的血浆尤应做抗体筛选以确保安全输血。

Screening Analysis of Irregular Antibodies from Random Donor Population in Shaoguan Area

The study was purposed to analyze the frequency and distribution of irregular antibodies in Shaoguan area.Screening 15 033 random donor antibodies in Shaoguan area by screening cells,polybrene and antiglobulin tests.The results indicated that the irregular antibodies were found in 42 samples.The freqnency of irregular antibodies in female was higher than that in male(P<0.001),and Rh blood group antibodies such as anti-D,anti-E,and anti-Ec C were common(47.6%).2 samples of Le antibodies were failed to be found by polybrene test.2 samples of irregular antibodies with titer 2 were undiscovered by screening test of 10 pooled samples.In concluson,because of irregular antibodies resulting in hemolytic transfusion reaction,the investigation of frequency and distribution of irregular antibodies is very important for safe transfusion.Antibody screening must be done for female donors,and especially for massive plasma transfusion of patients with severe and dangerous illness and infants so as to ensure safety.