| Changes of Regulatory T Cells in Graves' Disease |
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| 引用本文： | 王红祥,赵湜,唐晓琼,李菁媛,邹萍. Changes of Regulatory T Cells in Graves' Disease[J]. 华中科技大学学报(医学英德文版), 2006, 26(5) |
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| 作者姓名： | 王红祥 赵湜 唐晓琼 李菁媛 邹萍 |
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| 作者单位： | WANG Hongxiang ZHAO Shi TANG Xiaoqiong，LI Jingyuan，ZOU Ping |
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| 摘 要： | The immune mechanism of Graves' diseases (GD) and the roles of regulator T cells were investigated. In 32 patients with GD (GD group) and 20 healthy volunteers (control group), flow cy-tometry was used to detect the proportion of CD4 CD25 cells, MACS to isolate CD4 CD25 cells, RT-PCR to assay the expression of FOXP3, and ELISA to test the level of IL-10, respectively. It was found that there was no significant change in the proportion of CD4 CD25 T cells between GD group and control group (P>0.05), while secretion of IL-10 and expression of FOXP3 in GD group were lower than control group (P<0.01 and P<0.05, respectively). In conclusion, though the proportion of regulatory T cells of peripheral blood lymphocytes in the patients with GD, the functions of them were significantly weakened, which might be a pathogenic factor in GD.
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Changes of Regulatory T Cells in Graves' Disease |
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| WANG Hongxiang,ZHAO Shi,TANG Xiaoqiong,LI Jingyuan. Changes of Regulatory T Cells in Graves' Disease[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2006, 26(5) |
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| Authors: | WANG Hongxiang ZHAO Shi TANG Xiaoqiong LI Jingyuan |
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| Abstract: | The immune mechanism of Graves' diseases (GD) and the roles of regulator T cells were investigated. In 32 patients with GD (GD group) and 20 healthy volunteers (control group), flow cy-tometry was used to detect the proportion of CD4 CD25 cells, MACS to isolate CD4 CD25 cells, RT-PCR to assay the expression of FOXP3, and ELISA to test the level of IL-10, respectively. It was found that there was no significant change in the proportion of CD4 CD25 T cells between GD group and control group (P>0.05), while secretion of IL-10 and expression of FOXP3 in GD group were lower than control group (P<0.01 and P<0.05, respectively). In conclusion, though the proportion of regulatory T cells of peripheral blood lymphocytes in the patients with GD, the functions of them were significantly weakened, which might be a pathogenic factor in GD. |
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| Keywords: | Graves' disease regulatory T cell IL-10 FOXP3 |
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