斑蝥酸钠维生素B6联合替吉奥（S-1）治疗晚期胃肠道肿瘤的近期疗效观察

目的观察斑蝥酸钠维生素B6注射液联合替吉奥（s-1）治疗晚期胃肠道肿瘤的近期疗效及其不良反应。方法将42例晚期胃肠肠癌的患者随机分为两组，其中治疗组23例应用替吉奥基础上加用斑蝥酸钠维生素B。注射液进行治疗；对照组19例以替吉奥单药治疗。2个周期后评价近期疗效、临床效果及不良反应。结果治疗组CR（CompleteResponse）3例，PR（PartialResponse）10例，SD（StableDisease）8例，PD（ProgressionDisease）2例，总缓解率为56．5％；对照组CR1例，PR6例，SD7例，PD5例，总缓解率为36．8％，治疗组在疾病控制率上高于对照组，但在统计学上无显著性差异（P〉0．05）。在不良反应方面治疗组的主要毒副反应明显减轻，尤其在骨髓抑制及胃肠道反应方面，两组有显著性差异（P〈0．05）。结论斑蝥酸钠维生素B6注射液可增强胃肠道肿瘤病人的抗病能力，减轻化疗毒副作用，提高疗效。替吉奥单药口服治疗晚期胃肠道肿瘤的近期疗效肯定。

Clinical Observation on Effects of Sodium Cantharidate Vitamin B6 Injection Combined with S-1 Treatment of Advanced Gastrointestinal Tract Tumor Patients

Objective To observe the short-term effects and adverse reactions of treatments with combined sodium cantharidate Vitamin B6 injection and S-1 of metastatic gastrointestinal tract tumor. Methods A total of 42 patients with gastrointestinal cancer were randomly divided into two groups, the treatment group of 23 cases was treated with S-1 and Sodium Cantharidate Vitamin B6, the control group of 19 cases was treated with S-I. The short-term effects, clinical benefit response and adverse reactions were evaluated after two courses. Results Among 23 eases in treatment group, 3 CR, 10 PR, 8 SD and 2 PD, the total response rate was 56.5% . Among 19 eases in control group, 1 CR, 7 PR, 6 SD and 5 PD, the total response rate was 36, 8%. The Results showed no significant differences between the 2groups（P 〉 O. 05 ）. The major toxicities of treatment group were lightened obviously, especially the bone marrow suppression and gastrointestinal reactions, showed statistically significant differences between the 2groups （ P 〈 0. 05 ）. Conclusion Sodium cantharidate Vitamin B6 injection could enhance the disease resistance of gastrointestinal tract tumor patients, lighten the side effects of chemotherapy, and improve the curative effects. Sodium eantharidate Vitamin Be injection combined with S-1 were effective and tolerable in treatment patients with advanced gastrointestinal cancer.