非穿透性小梁切除联合丝裂霉素术后眼压日曲线的变化

目的观察原发性开角型青光眼非穿透性小梁切除术联合应用丝裂霉素的临床疗效及眼压日曲线变化。方法26例（26眼）原发性开角型青光眼行非穿透性小梁切除联合术中应用丝裂霉素，术后随访1年，观察术后眼压控制情况、眼压日曲线变化、峰谷眼压差值，视力、滤过泡、视野等情况。结果术前平均眼压（25．2±3．4）mmHg（1mmHg=0．133kPa），峰值眼压（34．7±4．3）mm—Hg，谷值眼压（15．5±3．1）mmHg，眼压波动值（19．2±3．3）mmHg；术后平均眼压（15．1±2．5）mmHg，峰值眼压（19．7±3．6mmHg），谷值眼压（10．4±2．8）mmHg，眼压波动值（9．3±2．2）mmHg，手术前后的平均眼压、峰值眼压、谷值眼压、眼压波动值的差异均有统计学意义。手术后平均眼压降低，眼压曲线峰谷差值缩小，眼压曲线趋于平稳。结论原发性开角型青光眼行非穿透性小梁切除联合丝裂霉素术后眼压控制较好，手术安全性较好，眼压日曲线峰谷差值缩小，近期效果较好，远期效果有待进一步观察。

Clinical observation on continuous 24-hour intraocular pressure curve after non-penetrating trabecu-lectomy with Mitomycin application.

Objective To analysis the continuous 24-hour intraoeular pressure （IOP） curve in pa- tients with primary open-angle glaucoma （POAG） after non-penetrating trabecular surgery （NPTS） with Mit- omycin application. Methods Twenty-six eyes of 26 patients with POAG that underwent non-penetrating trabeculectomy with Mitomycin application were studied. All patients were followed up for 1 year. 24-hour IOP monitoring, intraocular pressure, mean IOP, differential pressure, visual acuity, filtering bleb and visu- al fields were observed. Results Preoperative mean IOP was （ 25. 2 ± 3. 4 ） mmHg （ 1 mmHg = 0. 133 kPa）, the peak IOP was （34.7 ± 4.3） mmHg, the valley IOP was （ 15.5 ＋ 3.1 ） mmHg, the IOP fluctuation was （ 19.2 ± 3.3 ） mmHg. Postoperative mean IOP was （ 15.1 ± 2.5 ） mmHg, the peak IOP was （ 19.7 ± 3.6） mmHg, the valley IOP was （ 10.4 ± 2.8） mmHg, the IOP fluctuation was （9.3 ± 2.2） mm- Hg. There was significant difference between the preoperative items and the postoperative items in the 24- hour IOP curve. Conclusion Non-penetrating trabecular surgery with Mitomycin application is a safe and effective method of treating the primary open-angle glaucoma.