| 卡维地洛pH敏感性N-琥珀酰壳聚糖-海藻酸钙水凝胶的制备工艺优选 |
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| 引用本文： | 孟旬,李军民,李平,张海璇,魏琴. 卡维地洛pH敏感性N-琥珀酰壳聚糖-海藻酸钙水凝胶的制备工艺优选[J]. 中国医院药学杂志, 2011, 0(6) |
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| 作者姓名： | 孟旬 李军民 李平 张海璇 魏琴 |
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| 作者单位： | 兰州大学第二医院;兰州大学药学院; |
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| 基金项目： | 兰州市科技计划项目(编号:2009-1-55) |
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| 摘 要： | 目的:优选卡维地洛pH敏感性N-琥珀酰壳聚糖-海藻酸钙水凝胶的最佳制备工艺,并考察其pH敏感性。方法:以包封率和载药量为考察指标,采用L9(34)正交试验优选其制备工艺。评价水凝胶在不同pH值溶液中的pH敏感性。结果:优选的最佳工艺为2%(w/v)N-琥珀酰壳聚糖,2%(w/v)海藻酸钠,2%(w/v)氯化钙,药物与海藻酸钠的质量比为1∶4(g/g)。水凝胶在pH1.5的溶液中几乎不溶胀,在pH6.8的溶液中溶胀度最大。结论:优选的制备工艺合理可行,制备的水凝胶具有明显的pH敏感性及缓释效果。
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| 关 键 词： | 卡维地洛 N-琥珀酰壳聚糖 水凝胶 制备工艺 pH敏感性 |
Optimization on the preparing procedures of pH sensitive carvedilol loaded N-Succinyl chitosan-alginate hydrogel |
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| MENG Xun,,LI Jun-ming,LI Ping,ZHANG Hai-xuan,WEI Qin. Optimization on the preparing procedures of pH sensitive carvedilol loaded N-Succinyl chitosan-alginate hydrogel[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(6) |
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| Authors: | MENG Xun LI Jun-ming LI Ping ZHANG Hai-xuan WEI Qin |
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| Affiliation: | MENG Xun1,2,LI Jun-ming1,LI Ping1,ZHANG Hai-xuan1,WEI Qin1 (1.The Second Hospital of Lanzhou University,Gansu Lanzhou 730030,China,2.The Pharmacy College of Lanzhou University,Gansu Lanzhou 730000,China) |
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| Abstract: | OBJECTIVE To optimize the preparing technology of carvedilol loaded N-succinyl chitosan-alginate hydrogel,and investigate its pH sensitivity.METHODS Using entrapment efficiency and loading efficiency as indexes,the optimum preparing procedures for hydrogel was investigated with L9(34)orthogonal test.Also,the pH sensitivity was studied by swelling characteristics in different pH solutions.RESULTS The optimum preparing procedures for hydrogel were as follows:2%(w/v) N-succinyl-chitosan,2% sodium alginate,2%Ca... |
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| Keywords: | carvedilol N-succinyl chitosan hydrogel preparing technology pH sensitivity |
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