注射速率及时间分辨率对胶质瘤动态增强的影响

目的：探讨对比剂注射速率和序列时间分辨率对脑胶质瘤动态增强(DCE)的影响。方法收集行 MRI 检查并有颅脑占位性病变疑是胶质瘤的患者58例,分为2组,常规组41例,优化组17例。采用西门子 Verio3.0T 磁共振,8通道相阵控头部线圈,均行头部常规扫描、DCE-MRI 扫描。常规组对比剂注射速率3 mL/s,DCE 序列时间分辨率5.36 s,优化组对比剂注射速率4 mL/s, DCE 序列时间分辨率4 s 左右。2组病例应用 Tofts 模型进行后处理分析,对动脉输入函数(AIF)的曲线形态做优、中评估,2组计数资料行卡方检验。结果优化组 AIF 曲线形态明显优于常规组(P <0.05),差别有统计学意义。结论提高对比剂注射速率和DCE 序列时间分辨率对改进胶质瘤 DCE 图像质量是有意义的。

The influence of injection rate and time resolution on dynamic contrast-enhanced MR imaging of glioma

Objective To explore the influence of contrast agent injection rate and sequence time resolution on the dynamic contrast-enhanced MR iamging of brain glioma.Methods Fifty eight cases with suspected cerebral glioma were scanned on a Verio 3.0T MRI with the regular head sequences and DCE sequences.All the cases were divided into two groups.There were 41 cases in the regular group in which the injection rate was 3 mL/s and the time resolution was above 5.36 s.Another 1 7 cases were in the optimal group in which the injection rate was 4 mL/s and the time resolution was about 4 s.The DCE images of two groups were Postprocessed by the Tofts model analysis.The curve shape of AIF were evaluated and divided in to the excellent or the secondary level.Chi-square test was used to compare the results of two groups.Results The curve shape of optimal group was much better than that of regular group(P<0.05).Conclusion Speeding up the injection rate and the time resolution of DCE sequences would improve the image quality of DCE MRI of glioma.