MgSO_4对大鼠脑缺血-再灌注损伤电生理方面的影响

目的观察大鼠脑缺血－再灌注损伤时ＭｇＳＯ４对皮层脑电图、肢体运动功能及血Ｍｇ２＋浓度的影响。方法 用改良的大脑中动脉线栓法建立大鼠脑缺血－再灌注模型，进行皮层脑电图描记、血清Ｍｇ２＋浓度测定及运动功能 评估。结果　ＭｇＳＯ４能减少扩展性抑制波（ＳＤｓ）产生数（Ｐ＜０．０５）；１０％　ＭｇＳＯ４治疗组疗效优于５％ＭｇＳＯ４组，且早 期给药效果更佳（Ｐ＜０．０５）。结论ＭｇＳＯ４作为兴奋性氨基酸（ＥＥＡｓ）非竞争性Ｎ－甲基－Ｄ－天门冬氨酸受体（ＮＭＤＡ－ Ｒ）拮抗剂可有效减少ＳＤｓ产生数，对大鼠脑缺血－再灌注损伤有保护作用。

The electrophysical effect of MgSO_4 in rats with cerebral ischemia-reperfusion injury

Objective To observe the changes of conical spreading depressions (SDs), motive function and Mg2 concentration in serum in rats with ischemia-reperfusion treated by MgSO4 .Methods The animal model of reformed middle cerebral artery occlusion was made in 120 rats. The changes of cortical SDs and Mg2 concentration in serum in the rats were observed. Twenty-four hours after operation, the motive function was evaluated according to 0 - 5 grades.Results The motive function in rats was obviously improved after given higher dose of MgSO4 in earlier stage; MgSO4 significantly reduced the number of SDs; 10% MgSO4 has better neuroprotective effect than 5% MgSO4 and the much better effect was found in the MgSO4 group given in earlier stage. Conclusion MgSO4 as a non-competitive of NMDA-R can reduce the number of SDs significantly and exhibit protective effect during cerebral ischemia-reperfusion injury.