| 无细胞再生性牙髓治疗的现状及展望 |
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| 引用本文： | 周建,苏盈盈,王松灵.无细胞再生性牙髓治疗的现状及展望[J].华西口腔医学杂志,2022,40(1):1-6. |
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| 作者姓名： | 周建 苏盈盈 王松灵 |
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| 作者单位： | 1.首都医科大学口腔健康北京实验室，北京 1000692.首都医科大学附属北京口腔医院特诊特需科，北京 1000503.首都医科大学附属北京天坛医院口腔和全身健康融合与转化研究实验室，北京 1000704.首都医科大学附属北京天坛医院口腔科，北京 1000705.首都医科大学基础医学院，北京 100069 |
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| 基金项目： | 中国医学科学院牙齿发育与再生创新单元(2019-12M-5-031);北京市医院管理局使命计划(SML20151401);北京市教委人才培养项目(119207020201);“北京学者”计划项目(PXM-2020_014226_000005,PXM2019_014226_000039,PXM2019_014-226_000011,PXM2018_014226_000021,PXM2017_014226_0000-23,PXM2018_193312_000006_0028S643_FCG,PXM2016_01422-6_000034);国家自然科学基金委员会重大研究计划(91649124);国家自然科学基金委员会面上项目(82170951);北京市自然科学基金面上项目(7222079)。 |
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| 摘 要： | 患牙髓/根尖周病变的牙齿经过根管治疗后可得以保留,但是失去牙髓的患牙易发生再次感染和牙纵裂等并发症.随着组织工程和生物材料的发展,以生物学为基础的牙髓牙本质复合体再生或修复治疗成为可能.无细胞再生性牙髓治疗已经成为儿童和青少年年轻恒牙牙髓坏死的有效治疗方法,对成熟恒牙的治疗也在探索中.
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| 关 键 词： | 无细胞再生性牙髓治疗 细胞归巢 干细胞 组织工程 |
| 收稿时间： | 2021-06-16 |
| 修稿时间： | 2021-12-10 |
Progress and perspectives on cell-free regenerative endodontic therapy |
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| Zhou Jian,Su Yingying,Wang Song-ling.Progress and perspectives on cell-free regenerative endodontic therapy[J].West China Journal of Stomatology,2022,40(1):1-6. |
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| Authors: | Zhou Jian Su Yingying Wang Song-ling |
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| Institution: | (Beijing Laboratory of Oral Health,Capital Medical University,Beijing 100069,China;Dept.of VIP Dental Service,Beijing Stomatological Hospital,Capital Medical University,Beijing 100050,China;Laboratory for Oral and General Health Integration and Translation,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Dept.of Stomatology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China) |
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| Abstract: | Although teeth with pulpitis/apical periodontitis are saved after successful endodontic therapy, they are devitalized and susceptible to reinfections and fractures. The development of biology-based approaches for dental pulp regeneration or repair is possible today because of recent advances in tissue engineering and biomaterials. Cell-free regenerative endodontic therapy offers a promising strategy for the treatment of necrotic immature permanent teeth in children and adolescents. However, studies are underway to determine whether this procedure can be applied to mature teeth. |
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| Keywords: | cell-free regenerative endodontic therapy cell homing stem cell tissue engineering |
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