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Chromene-Based Synthetic Chalcones as Potent Antileishmanial Agents: Synthesis and Biological Activity |
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| Authors: | Alireza Foroumadi Saeed Emami Maedeh Sorkhi Maryam Nakhjiri Zohreh Nazarian Samaneh Heydari Sussan K. Ardestani Fatemeh Poorrajab Abbas Shafiee |
| Affiliation: | 1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran;2. Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;3. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran;4. Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran;5. Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, PO Box 13145-1384, Tehran, Iran |
| Abstract: | Two types of regioisomeric chromene-based chalcones namely, 1-(6-methoxy-2H-chromen-3-yl)-3-phenylpropen-1-ones and 3-(6-methoxy-2H-chromen-3-yl)-1-phenylpropen-1-ones were prepared and investigated for their antileishmanial activity against promastigotes form of Leishmania major. The obtained results from in vitro biological assays indicated that chloro-substituted 1-(6-methoxy-2H-chromen-3-yl)-3-phenylpropen-1-ones exhibited excellent activity against Leishmania major at non-cytotoxic concentrations. |
| Keywords: | antileishmanial activity chalcones chromene Leishmania major promastigotes |