Signalling and pharmacological properties of the P2Y14 receptor |
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| Authors: | T. K. Harden J. I. Sesma I. P. Fricks E. R. Lazarowski |
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| Affiliation: | Departments of Pharmacology and Medicine and the Cystic Fibrosis Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA |
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| Abstract: | The P2Y14 receptor is a relatively broadly expressed G protein-coupled receptor that is prominently associated with immune and inflammatory cells as well as with many epithelia. This receptor historically was thought to be activated selectively by UDP-glucose and other UDP-sugars. However, UDP is also a very potent agonist of this receptor, and may prove to be one of its most important cognate activators. |
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| Keywords: | Gi immunological response nucleotide nucleotide sugar P2Y receptor UDP |
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