Toll-like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis |
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| Authors: | Y Xue Z Q Zhao H J Wang L Jin C P Liu Y Wang J C Li |
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| Institution: | 1. Institute of Cell Biology, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China;2. School of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China;3. The Sixth Hospital of Shaoxing, Shaoxing, China;4. Jilin Academy of Traditional Chinese Medicine Sciences, Changchun, China |
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| Abstract: | Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp299Gly, Thr399Ile) were investigated in 205 tuberculosis (TB) patients and 203 controls. Genetic variations were analysed by DNA sequencing. We revealed that these polymorphisms were rare in the southeastern Chinese population and were not associated with susceptibility to TB. |
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