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Role of adipokines in obesity-associated hypertension |
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| Authors: | M. Vlasova A. K. Purhonen M. R. Jarvelin E. Rodilla J. Pascual K. H. Herzig |
| Affiliation: | 1. Department of Pharmaceutics, University of Kuopio, Kuopio, Finland Both authors contributed equally to the manuscript.;2. Department of Physiology, Institute of Biomedicine, Oulu University Medical School, Oulu, Finland Both authors contributed equally to the manuscript.;3. Department of Lifecourse and Services, National Institute of Health and Welfare, Oulu, Finland;4. Department of Epidemiology and Public Health, Imperial College London, London, UK Biocenter of Oulu, Oulu, Finland;5. Hypertension Clinics, Sagunto Hospital, University of Valencia, Valencia, Spain;6. Department of Physiology, Institute of Biomedicine, Oulu University Medical School, Oulu, Finland Biocenter of Oulu, Oulu, Finland Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland |
| Abstract: | It has been well documented that obesity is a major risk factor for the development of the hypertensive state. The correlation between body mass index and blood pressure level is well established. Nevertheless, the exact mechanisms which contribute to obesity-related hypertension remain poorly understood. In the last years, we have realized that the white adipose tissue is not just an inert organ for nutrient storage and isolation but rather depending on the body mass index the biggest endocrinological organ. Thus, the possible contribution of adipokines to the blood pressure elevation becomes an attractive hypothesis to explain the hypertensive state that often occurs in obesity. In this review, we consider direct and indirect effects of main adipokines on structural and functional changes in the cardiovascular system. |
| Keywords: | adipokines cytokines hypertension inflammation metabolic syndrome obesity |