The neuronal regulation of fracture healing: Effects of sciatic nerve resection in rat tibia |
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Authors: | Lars Nordsletten Jan Erik Madsen Runar Almaas Terje Rootwelt Johan Halse Yrj T. Konttinen Mika Hukkanen Seppo Santavirta |
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Affiliation: | Lars Nordsletten ,Jan Erik Madsen,Runar Almaas,Terje Rootwelt,Johan Halse,Yrjö, T. Konttinen,Mika Hukkanen,Seppo Santavirta |
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Abstract: | The effect of sciatic nerve resection on tibial fracture healing was studied in rats 25 days post-trauma. To prevent differences in loading between sham-operated and nerve-resected animals the fractured limbs were cast-immobilized. On radiograms 8 of 11 fractures in the sham-operated animals showed very little callus formation in contrast to only 1 of 8 fractures in the group with nerve resection. Measured by single-photon absorptiometry, animals with sciatic nerve resection had a higher bone mineral content than the sham-operated animals. However, the mechanical strength in three-point cantilever bending was not better in the nerve-resected rats, implying a defective organization of the large callus. These results suggest neural regulation plays a role in the type of fracture healing, primary or secondary, and in the amount and quality of the callus. |
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