| 女贞子及其成分齐墩果酸对环磷酰胺及乌拉坦引起染色体损伤的保护作用 |
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| 引用本文： | 女贞子及其成分齐墩果酸对环磷酰胺及乌拉坦引起染色体损伤的保护作用[J]. 中国药科大学学报,1987,(3): 222-224. |
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| 作者姓名： | 杭秉茜 戴岳 巫冠中 迪丽努尔 赵琳 谭立武 |
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| 作者单位： | 中国药科大学药理学教研室，中国药科大学药理学教研室，中国药科大学药理学教研室，中国药科大学，中国药科大学，长沙中药厂研究室 本校研究生，1986届毕业生，1986届毕业生 |
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| 摘 要： | 女贞子(Fructus Ligustri Lucidi,FLL)是木犀科植物女贞Ligustrum lucidum Ait.成熟的果实,是中医常用的扶正药,具有滋阴、补肝肾作用。研究表明女贞子能多环节地影响机体的免疫功能,其水煎剂可抑制小鼠子宫颈癌,这与中医的“扶正祛邪”有相似之
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| 关 键 词： | 女贞子 齐墩果酸 微核试验 |
PROTECTION OF FRUCTUS LIGUSTRI LUCIDI AND OLEANOLIC ACID ON THE CHROMOSOMAL DAMAGE INDUCED BY CYCLOPHOSPHAMIDE AND URETHAN |
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| PROTECTION OF FRUCTUS LIGUSTRI LUCIDI AND OLEANOLIC ACID ON THE CHROMOSOMAL DAMAGE INDUCED BY CYCLOPHOSPHAMIDE AND URETHAN[J]. Journal of China Pharmaceutical University,1987,(3): 222-224. |
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| Authors: | Hang Bingqian Dai Yue Wu Guanzhong Dili Nuer Zhao Ling Tan Liwu |
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| Affiliation: | Department of Pharmacology; ~*Division of Changsha Traditional Chinese Pharmaceutical Works |
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| Abstract: | Protection effect of Fructus Ligustri Lucidi (FLL) and oleanolic acid on the chromosomal damage by counting the frequency of micronucleus in mouse hone-marrow was studied. Mice were given either FLL (decoction) 12.5, 25g/kg/d po 6d or oleanolic acid 50, 75, 100mg/kg/d sc 7d.Cyclophosphamide (Cy) 50mg/kg/d ip on the last two days or urethan 500 mg/kg/d on the last four days was given. The frequency of micronuclei induced by Cy was reduced 59.7%, 74.3% by FLL 12.5g/kg,25g/kg, and reduced 41.3%, 79.9% by oleanolic acid 50mg/kg, 100mg/kg respectively. The frequency of micronuclei induced by urethan was reduced 53.3%, 70.1% by FLL 12.5g/kg, 25g/kg, and reduced 45.1%, 58.4% and 76.9% by oleanolic acid of 50mg/kg, 75mg/kg and 100mg/kg respectively. |
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| Keywords: | Fructus Ligustri Lucidi Oleanolic acid Micronucleus test |
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