| 乳腺癌患者nm23基因的表达及临床意义 |
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| 引用本文： | 郑苏文,赵祥生,唐金海,俞乔,李立. 乳腺癌患者nm23基因的表达及临床意义[J]. 江苏医药, 2000, 26(7): 531-532 |
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| 作者姓名： | 郑苏文 赵祥生 唐金海 俞乔 李立 |
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| 作者单位： | 210009,江苏省肿瘤防治研究所普外科 |
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| 摘 要： | 目的 分析人ｎｍ２３基因表达乳腺癌的转移、复发及估计预后的关系。方法 应用ｓｐ免疫组化当检测１８０例中患者中ｎｍ２３基因蛋白的表达。结果 显示ｎｍ２３基因在９９例（５５％）有表达。研究表明ｎｍ２３基因的表达与原发瘤体大小、淋巴转移、这分级显著相关（Ｐ〈０．０１），与淋巴结转移程度呈负相关（Ｐ〈０．０５）。而与月经状况及癌周围浸胸无相关（Ｐ〉０．０５）。结论 提示人ｎｍ２３基因表达可作为临床对乳腺癌
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| 关 键 词： | 乳腺癌 nm23基因 预后 基因表达 |
Expression of oncogene nm23 in breast cancer and its clinical significance-A report of 180 cases |
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| ZHENG Suwen,ZHAO Xiangsheng,TANG Jinhai et al. Expression of oncogene nm23 in breast cancer and its clinical significance-A report of 180 cases[J]. Jiangsu Medical Journal, 2000, 26(7): 531-532 |
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| Authors: | ZHENG Suwen ZHAO Xiangsheng TANG Jinhai et al |
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| Affiliation: | ZHENG Suwen,ZHAO Xiangsheng,TANG Jinhai et al. Department of General Surgery,Jiangsu Cancer Hospital,Nanjing,210009 |
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| Abstract: | Objective To study the correlation between the expression of nm23 and the metastasis,recurrence and prognosis of breast cancer.Methods The expression of oncogene nm23 protein in 180 cases of breast cancer were determined with immunohistochemical SP method.Results The nm23 expressed in 99 cases (55%).The results showed that the expression of nm23 was inversely correlated with the tumor size,lymph node involvement,histologic grade ( P <0 01) and the degree of nodul metastasis ( P <0 05).The oncogene expression has no relationship with menstruation and tumor peripheral infiltration ( P >0 05).Conclusion It was suggested that the expression of nm23 was a useful clinical index in evaluating the metastasis,recurrence and prognosis of breast cancer. |
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| Keywords: | Breast cancer Oncogene nm23 Prognosis |
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