奥美拉唑和兰索拉唑治疗168例消化性溃疡的临床观察

目的探讨兰索拉唑对消化性溃疡（PU）的临床疗效及应用价值。方法选取在我院治疗的Pu患者168例，随机分为观察组和对照组，两组采用相同的西医常规治疗方案，对照组给予奥美拉唑进行治疗，观察组给予兰索拉唑进行治疗，观察两组的临床疗效及不良反应发生情况。结果观察纽治愈45例，显效2l例，有效14例，无效4例，总有效率为95．24％；对照纽治愈22例，显效30例，有效18例，无效14例，总有效率为83．33％，两组临床疗效比较，差异有统计学意义（P〈0．05）。观察组不良反应发生率为5．95％，对照组不良反应发生率为10．71％，观察组不良反应发生率低于对照组，但经统计学分析比较，差异无统计学意义（P〉O05）。两组治疗有效患者随访1年后，观察组复发率为21．25％，对照组复发率为38．57％，两组复发率比较，差异有统计学意义（P〈0．05）。结论采用兰索拉唑治疗PU的临床疗效优于奥美拉唑，幽门螺旋杆菌（Hp）根除率高，不良反应轻微，值得在临床上大力推广使用。

Comparative analysis of omeprazole and lansoprazole in the treatment of peptic ulcer

Objective To explore the clinical treatment of lansoprazole for peptic ulcer effect and application value. Methods Choose our hospital treatment of 168 patients with peptic ulcer were randomly divided into observation group and control group, two groups use the same western medicine routine treatment, control group given omeprazole for treatment, the observation group was given lansoprazole treatment, observe two groups of clinical curative effect and adverse reaction occurred. Results Observation group 45 cases cured, 21 cases were markedly effective, effective 14 cases, 4 cases were invalid, the total effective rate was 95.24%; Control group cure 22 cases, 30 cases were markedly effective, effective 18 cases, 14 cases, the total effective rate was 83.33%, compared two groups of clinical curative effect, through the statistical analysis of the difference was statistically significant （P〈0.05）. Observation group, the incidence of adverse reactions was 5.95%, control group is 10.71 incidence of adverse reactions, observation group is lower than the control group, the incidence of adverse reaction but after statistics analysis and comparison, there was no statistically significant difference （P〉0.05）. Effective patients treated in the two groups were followed up for 1 years later, the observation group recurrence rate was 21.25%, control group recurrence rate was 38.57%, two groups of recurrence rate comparison, the statistical analysis of the difference was statistically significant （P〈0.05）. Conclusion Using lansoprazole clinical curative effect of treatment of peptic ulcer due to omeprazole, h. pylori eradication rate is high, the mild adverse reaction, is worth popularizing in clinical use.