经桡动脉行冠状动脉介入中血管解痉药物的对比研究

目的 观察血管解痉药乌拉地尔和硝酸甘油对桡动脉痉挛的效果。方法 选取2005年1月～2006年12月Au。。实验阳性并经桡动脉途径行冠状动脉造影及经皮冠状动脉介入治疗的患者180例，其中男性160例，女性20例；平均年龄68±11（37～78）岁。将患者随机分为A组和B组，两组间年龄、性别差异无显著性（P〉0．05）。A组为乌拉地尔组（90例），B组为硝酸甘油组（90例）。桡动脉穿刺成功后，A组常规鞘入乌拉地尔12．5mg，B组常规鞘入硝酸甘油200μg，然后行CAG和PCI术，观察桡动脉痉挛发生率。结果 A组桡动脉痉挛发生率2．22％（2／90），B组桡动脉痉挛发生率12．22％（11／90），两组间桡动脉痉挛发生率差异有显著性（P〈0．05）。结论 乌拉地尔对缓解桡动脉痉挛作用效果好。

Comparison Study of Arterial Anticonvulsive Drug in Percutaneous Radial Artery Approach for Coronary Intervention

Objective To evaluate the effect of nitroglycerin and urapidil on relaxing spasm of radial artery, in percutaneous radial artery approach for coronary intervention（PCI）. Methods 180 patients（mean age： 68± 11 years, 160 male） on Jan, 2005 to Dec, 2006 were collected. All of the 180 patients received percutaneous radial artery approach for coronary intervention and were divided into group A and group B by arterial injection with urapidil or nitroglycerin. The age and gender of patients were no significant difference in two groups. After puncture of the radial artery successfully, the patients in group A were arterial injection urapidil and group B arterial injection nitroglycerin. All of patients received PCI. Observe the incidence of radial arteriospasm. Results As for the two groups, the incidence of radial arteriospasm was 2.22 percent（2/90） vs 12.22 pereent（ll/90）. This difference was significant and had statistical significance（P〈 0.05）. Conclusion The urapidil is better than nitroglycerin in relaxing spasm of radial artery.