两周CHOP方案治疗非霍奇金淋巴瘤临床疗效观察

目的:评价两周CHOP方案治疗非霍奇金淋巴瘤(NHL)的疗效及不良反应。方法:对2000年1月至2004年10月68例非霍奇金淋巴瘤随机分为两周方案组(CHOP/2W)及三周方案组(CHOP/3W),每组34例,全部经病理及免疫组化证实。全部采用CHOP方案化疗,CTX750mg/m²d1、ADM50mg/m²d1、VCR1.4mg/m²d1、PDN100mgd1～5。两周方案组,从第5天至第11天开始行G-CSF预防白细胞下降。结果:两周方案有效率为97.1%,三周方案有效率为79.4%(P＜0.05)。两组患者的不良反应均无明显差异(P＞0.05)。结论:两周方案治疗NHL是一种安全、有效的治疗方案。

The Studies on Clinical Efficacy of Biweekly Regimen of CHOP Chemotherapy on Non-Hodgkin's Malignant Lymphoma

Objective: To evaluate the efficacy of biweekly and triweekly CHOP regimen for treat-ment on the malignant lymphoma. Methods: From Jan 2000 to Oct 2004, 68 patients with histologically and immunohistochemically confirmed non-Hodgkin's lymphoma were randomized into two groups. Bi-weekly CHOP group (CHOP/2w) and triweekly CHOP group (CHOP/3w), received CTX 750mg/m 2 d1 、ADM 50 mg/m 2 d1、VCR 1.4mg/m 2d1、 PDN 100mg d1-5.The patients of biweekly CHOP group re-ceived G-CSF200ug qd iH on d5-11. Results: The response rate (RR) of biweekly CHOP group with 97.1% effective rate (70.5% complete response [CR] and 26.5% partial response [PR]) was better com-pared to triweekly CHOP group with 79.4% effective rate (50% CR and 29.4% PR). (P<0.05). The sideeffect of the two groups is of no significant difference (P>0.05). Conclusions: The results of this studyshow that the biweekly regimen of CHOP chemotherapy on NHL is effective and safe.