| 地诺帕明对·OH致大鼠异常血流动力学的保护作用 |
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| 引用本文： | 黄燮南,吴伦宽,刘国雄,吴芹.地诺帕明对·OH致大鼠异常血流动力学的保护作用[J].中国药理学通报,1994(6). |
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| 作者姓名： | 黄燮南 吴伦宽 刘国雄 吴芹 |
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| 作者单位： | 遵义医学院药理学教研室，贵阳医学院附院内科 |
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| 摘 要： | ｉｖ羟自由基（·ＯＨ）生成液５ｍｌ·ｋｇ－１使麻醉大鼠心功能明显受损，表现为ＬＶＳＰ、ＬＶＳＰ×ＨＲ、ＭＡＰ、＋ｄｐ／ｄｔｍａｘ和－ｄｐ／ｄｔｍａｘ明显降低，而ＬＶＥＤＰ显著升高。在给ＯＨ前５ｍｉｎｉｖ地诺帕朗１８μｇ·ｋｇ－１，再以３０μｇ·ｋｇ－１·ｍｉｎ－１于给·ＯＨ后立即静脉输注，可不同程度地改善上述异常血流动力学指标，其中对ＬＶＥＤＰ的改善尤为显著。地诺帕朗还明显对抗·ＯＨ所致血浆丙二醇含量的升高。本文就其临床意义作了讨论。
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| 关 键 词： | 地诺帕明，羟自由基，血流动力学，丙二醛 |
Protective effects of denopamine on the abnormal hemodynamics induced by·OH in anaesthetized rats |
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| HUANG Xie-Nan,WU Lun-Kuan,LIU Guo-Xiong,WU Qin.Protective effects of denopamine on the abnormal hemodynamics induced by·OH in anaesthetized rats[J].Chinese Pharmacological Bulletin,1994(6). |
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| Authors: | HUANG Xie-Nan WU Lun-Kuan LIU Guo-Xiong WU Qin |
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| Abstract: | The effects of denopamine (Deno)on the abnormal hemodynamics indued by exogenous hydroxyl free radical (.OH) were investigated in anaesthetized rats.Intravenous administration of. OHgenerating solution (H2O2 1 mmol. L-1 with equlmolar CuCl2 and vitamin C) 5 ml. kg-1 significantly decreased LVSP×HR,MAP,+dP/dtmax and-dP/dtmax,and increased LVEDP in anaesthetized rasts. These effects continued in the whole surveying period(1h).Preadministration(iv,5 min before. OH) of Deno 180μg.kg-1 followed by intravenous infusion of 30μg. Kg-1. Min-1 after administration of. OH significantly improved these abnormal hemodynamic indices induced by.OH except LVSP.The improvement of LVEDP was specifically significant.Furthermore, the heightened serum malondialdehyde(MAD) content induced by.OH was also decreased by Deno.The clinical significance was discussed. |
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| Keywords: | denopamine hydroxyl free radical hemodynamics malondialdehyde |
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