Histochemical Studies of Testicular δ5 -3β-Hydroxysteroid Dehydrogenase and 17β-Hydroxysteroid Dehydrogenase after Chronic Indomethacin Administration in Rats Pretreated with Clomiphene-Citrate |
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| Authors: | S. SANYAL P.B. PATRA and N.M. BISWAS |
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| Affiliation: | Department of Physiology, University of Calcutta/India |
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| Abstract: | Histochemical studies of testicular delta5-3beta-Hydroxysteroid Dehydrogenase and 17beta-Hydroxysteroid Dehydrogenase in sexually immature rats treated chronically with simultaneous Indomethacin and Clomiphene revealed greater inhibition in the enzyme activities when compared to Clomiphene treated animals alone. This suggests prostaglandin-inhibitors may be directly inhibitory to NAD-requiring enzymes involved in testicular steroid biosynthesis. |
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| Keywords: | Clomiphene indomethacin rat testis testicular dehydrogenase testicular steroidogenesis |
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