| 大鼠急性脊髓损伤动物模型的建立及影像学分析* |
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| 引用本文： | 杨进顺,吕浩然,廖壮文,赵玉,谭理连.大鼠急性脊髓损伤动物模型的建立及影像学分析*[J].广东医学,2011,32(5). |
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| 作者姓名： | 杨进顺 吕浩然 廖壮文 赵玉 谭理连 |
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| 作者单位： | 广州医学院第二附属医院骨外科 |
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| 基金项目： | 广东省自然科学基金，广州市属高校科技计划项目 |
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| 摘 要： | 目的 建立一种大鼠急性脊髓损伤的动物模型,分析模型影像特征及诊断价值.方法 32只小鼠随机分为对照组(5只)和实验组(27只),对照组只暴露T9～11脊髓,实验组显露T9～11脊髓后采用钳夹法致伤.伤后行运动功能BMS评分,术后对模型均行脊柱X线片、CT、MRI检查.结果 实验组后肢运动功能损伤均明显,BMS评分与对照组差异有显著性 (P＜0.01); X线片可见胸椎T9～11局部骨质缺失;CT可见损伤脊髓周围组织有异常信号,但边界不清;MRI可见实验组损伤的脊髓组织T2异常强化,范围清楚,局部渗出液积聚.结论 钳夹损伤建立了可靠的脊髓损伤动物模型,MRI检查对大鼠的急性脊髓损伤具有很高的敏感性和准确性.
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| 关 键 词： | 脊髓损伤 动物模型 影像学 |
Radiology image evaluation in mouse model of acute spinal cord injury. |
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| YANG Jin-shun,LV Hao-ran,LIAO Zhuang-wen,ZHAO Yu,TAN Li-lian.Radiology image evaluation in mouse model of acute spinal cord injury.[J].Guangdong Medical Journal,2011,32(5). |
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| Authors: | YANG Jin-shun LV Hao-ran LIAO Zhuang-wen ZHAO Yu TAN Li-lian |
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| Institution: | YANG Jin-shun,LV Hao-ran,LIAO Zhuang-wen,ZHAO Yu,TAN Li-lian.Department of Orthopaedics,The Second Hospital Affiliated of Guangzhou Medical College,Guangzhou 510260,China |
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| Abstract: | Objective To establish a mouse model of spinal cord injury(SCI),of which the imaging features were analyzed for evaluation of diagnostic significance.Methods A total of 32 mice were randomly divided into experimental group(n=27) and control group(n=5),in which mice received thoracic 9~11 spinal cord clamped injury and sham operation,respectively.Basso Mouse Scale(BMS),X-ray,CT and MRI were performed for assessment.Results Significant reduction of BMS was revealed in experimental group(P<0.01).Bone defected ... |
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| Keywords: | spinal cord injury animal model radiology |
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