HBsAg疫苗冲击树突状细胞联合乙肝免疫球蛋白对慢性乙型肝炎及HBV携带者的疗效

目的:观察HBsAg疫苗冲击的树突状细胞与乙肝免疫球蛋白联合应用对慢性乙型肝炎的疗效．方法:慢乙肝患者66例每月1次注射HBsAg疫苗(106／次)冲击的树突状细胞,乙肝免疫球蛋白200 U／次,6次为1疗程,共2疗程,治疗结束后检查肝功能,HBV DNA定量及乙肝标志．结果:HBeAg阳性慢乙肝27例治疗后有7例显示完全应答,14例显示部分应答．HBeAg阴性的慢乙肝15例中有4例出现完全应答,8例显示部分应答．慢性HBV携带者13例中5例显示完全应答,2例表现为部分应答．11例非活动性 HBsAg携带者中2例出现完全应答．结论:HBsAg疫苗冲击的树突状细胞与乙肝免疫球蛋白联合可试用于慢乙肝的治疗．

Efficacy of HBsAg vaccine-pulsed dendritic cells combined with hepatitis B immunoglobulin in treatment of chronic hepatitis B patients and hepatitis B virus carriers

AIM: To investigate the potential effect of HBsAg vaccine-pulsed dendritic cells (DC) combined with hepatitis B immunoglobulin (HBIg) on chronic hepatitis B (CHB) patients and hepatitis B virus (HBV) carriers. METHODS: HBsAg vaccine-pulsed DC (106) and HBIg (200 U) were injected into 66 CHB patients once a month, respectively. Six months were considered as one course, and there were two courses in total. At the end of treatment, liver function, HBV DNA level and HBV markers in the patients were measured. RESULTS: Of the 27 patients with HBeAg( ) CHB, 7 showed complete responses, and 14 showed partial responses. Of the 15 patients with HBeAg(-) CHB, complete responses were observed in 4 patients, and partial responses were observed in 8 cases. Of the 13 chronic HBV carriers, complete responses occurred in 5 cases, and partial responses occurred in 2 cases. Of the 11 inactive HBsAg carriers, 2 cases showed complete responses. CONCLUSION: HBsAg vaccine-pulsed DC with HBIg is effective in the treatment of CHB patients and HBV carriers.