| 5-羟色胺与肠易激综合征的内脏高敏感性 |
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| 引用本文： | 张丽妍,陈胜良. 5-羟色胺与肠易激综合征的内脏高敏感性[J]. 胃肠病学, 2009, 14(8): 502-504. DOI: 10.3969/j.issn.1008-7125.2009.08.015 |
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| 作者姓名： | 张丽妍 陈胜良 |
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| 作者单位： | 上海交通大学医学院附属仁济医院消化内科,上海市消化疾病研究所,2000131 |
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| 摘 要： | 肠易激综合征（IBS）是一种常见的功能性胃肠病，由于缺少明确的结构和生化改变，其临床诊断和治疗均有～定难度。目前认为内脏高敏感性和胃肠道动力异常是IBS的病理生理基础，近年来探索内脏高敏感性的形成机制成为IBS研究的热点。研究显示5-羟色胺（5-HT）可能与内脏高敏感性相关。5-HT相关制剂用于IBS的治疗已取得一定疗效。5-HT在内脏高敏感性形成机制中作用的研究将有助于IBS病理生理机制的阐明和临床新药的开发。
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| 关 键 词： | 血清素 受体，血清素 肠易激综合征 内脏高敏感性 |
5-Hydroxytryptamine and Visceral Hypersensitivity in Irritable Bowel Syndrome |
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| ZHANG Liyan,CHEN Shengliang. 5-Hydroxytryptamine and Visceral Hypersensitivity in Irritable Bowel Syndrome[J]. Chinese Journal of Gastroenterology, 2009, 14(8): 502-504. DOI: 10.3969/j.issn.1008-7125.2009.08.015 |
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| Authors: | ZHANG Liyan CHEN Shengliang |
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| Affiliation: | ZHANG Liyan, CHEN Shengliang (Department of Gastroenteralog), Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai Institute of Digestive Disease, Shanghai 200001) |
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| Abstract: | Irritable bowel syndrome （IBS） is a commonly seen functional gastrointestinal disorder. Its diagnosis and treatment are difficult due to lack of explicable structural and biochemical abnormalities. Now visceral hypersensitivity and abnormal motility are considered as the two basic pathophysiologic mechanisms and scientists have paid more attention to visceral hypersensitivity. It was demonstrated that 5-hydroxytryptamine （5-HT） might be related to visceral hypersensitivity, agonist and antagonist of 5-HT have all been used in the treatment of IBS with good efficacy. Investigations on the role of 5-HT in visceral hypersensitivity would benefit the clarification of its pathophysiologie mechanism and development of new drug for the treatment of IBS. |
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| Keywords: | Serotonin Receptors, Serotonin In＇itable Bowel Syndrome Visceral Hypersensitivity |
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