| 狼疮肾炎尿毒症预后的影响因素探讨 --附102例报告 |
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| 引用本文： | 黄辉,黄湖辉,宛霞,李劲高.狼疮肾炎尿毒症预后的影响因素探讨 --附102例报告[J].新医学,2003,34(3):159-161. |
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| 作者姓名： | 黄辉 黄湖辉 宛霞 李劲高 |
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| 作者单位： | 中山大学附属第二医院肾内科,510120 |
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| 摘 要： | 目的:探讨影响狼疮肾炎尿毒症患者预后的因素,为控制尿毒症的发生和发展提供依据。方法:通过随访方式追踪狼疮肾炎尿毒症患者的临床、实验室及治疗的资料,采用COX回归模型,进行单因素及多因素分析。结果:102例狼疮肾炎尿毒症患者中,有37例死亡(占36.3%),多因素分析显示血尿酸、Ccr、肾萎缩与否和血尿素氮对预后有显著影响,且为独立因素,而临床分型、性别、狼疮活动指数和血肌酐并不是影响预后的独立因素。结论:高水平的尿酸和血尿素氮为独立危险因素,而肾无萎缩和Ccr的维持有利于肾功能的改善。
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| 关 键 词： | 系统性红斑狼疮 肾炎 狼疮肾炎 尿毒症 预后 |
| 修稿时间： | 2002年9月25日 |
Factors influencing prognosis of lupus nephritis uremia |
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| Huang Hui,Huang Huhui,Wan Xia,et al..Factors influencing prognosis of lupus nephritis uremia[J].New Chinese Medicine,2003,34(3):159-161. |
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| Authors: | Huang Hui Huang Huhui Wan Xia |
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| Institution: | Huang Hui,Huang Huhui,Wan Xia,et al.Renal Department,Sun Yat-sen Memorial Hospital of SunYat -sen University,Guangzhou,510120,China |
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| Abstract: | Objective:To study factors influencing prognosis of lupus nephritis uremia.Methods :Clinical data of lupus nephritis uremia were collected and analyzed by COX regression.Results:Among 102cases,37patients died.Multivariate analysis revealed that uric acid,endogenous creatinine clearance,size of kidney and blood urea nitroge n had significant impact on progno-sis,while clinical type,sex,systemic lupus erythematosus disea se activity index(SLEDAI )and blood creatinine did not influen ce prognosis.Conclusion:High concentration of blood uric acid and blood urea nitrogen are indepen dent risk factors,while mainte-nance of endogenous creatinine clea rance and normal-sized kidney is imp ortant in improving renal function. |
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| Keywords: | Systemic lupus erythematosus Nephr itis Lupus Nephritis Uremia Prognosis |
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