| 循环DNA在大肠癌中的应用 |
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| 引用本文： | 黄宗华,徐丹丹,张飞艳,宋丽华,宋现让.循环DNA在大肠癌中的应用[J].国际肿瘤学杂志,2016,43(2):152-154. |
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| 作者姓名： | 黄宗华 徐丹丹 张飞艳 宋丽华 宋现让 |
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| 作者单位： | 1. 250022 济南大学山东省医学科学院医学与生命科学学院;山东省肿瘤医院内科;2. 山东省医学科学院附属医院内二科;3. 山东省肿瘤医院内科 |
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| 摘 要： | 循环DNA是一种存在于血浆、脑脊液及滑液等体液中的细胞外DNA.肿瘤患者循环DNA的含量明显高于健康人群,并具有与肿瘤发生、发展相关的特征性改变,例如基因突变、DNA甲基化、微卫星不稳定性等.循环DNA的定量与定性检测,在肿瘤的筛查、诊断、病情的监测以及预后评价中均有潜在的价值.
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| 关 键 词： | 结直肠肿瘤 循环DNA |
Application of circulating DNA in colorectal cancer |
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| Institution: | School of Medicine and Life Science, University of Ji′nan , Shandong Academy of Medical Sciences, Department of Medicine, Shandong Cancer Hospital and Institute, Ji′nan 250022, China |
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| Abstract: | Circulating DNA is defined as a kind of extracellular DNA that exists in plasma,cerebrospinal fluid and synovial fluid.The concentration of circulating DNA of cancer patients is significantly higher than that in healthy people.The genetic and epigenetic alterations of circulating cell-free nucleic acids are relevant to cancer development and progression,for example,gene mutation,DNA methylation and microsatellite instability and so on.The quantitative and qualitative detection of circulating DNA shows promising potential value in cancer screening,diagnosis,disease monitoring treatment and prognosis. |
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| Keywords: | Colorectal neoplasms Circulating DNA |
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